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Association of CYP1A1 polymorphisms with prostate cancer risk: an updated meta-analysis

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Abstract

Epidemiological studies have evaluated the association between 3801T>C and 2455A>G polymorphisms of cytochrome P450 1A1 (CYP1A1) and prostate cancer risk. However, controversy exists regarding the role of these polymorphisms. In this work, a meta-analysis was performed to derive a more precise estimation of the relationship. PubMed and ISI Web databases were searched for all cases dated until March 2012. Crude odds ratios with 95 % confidence intervals were used to assess the strength of the association between CYP1A1 polymorphisms and prostate cancer risk. Sensitivity analysis, excluding the studies that deviated from the Hardy–Weinberg equilibrium (HWE), was performed. A total of 17 studies fulfilled our inclusion criteria in this meta-analysis, 12 of which were eligible (1,645 cases and 1,801 controls) for 3801T>C, and eleven (1,640 cases and 1,959 controls) were eligible for 2455A>G. Overall, the 2455A>G polymorphism resulted in a significantly increased susceptibility to prostate cancer. In addition, no significant associations between 3801T>C polymorphism and prostate cancer susceptibility were found in all genetic models. Only an elevated risk was observed for TC versus CC in Asian studies. However, no relationship was found in the Asian group for TC versus CC after excluding the studies that deviated from HWE. Thus, this meta-analysis finds the 2455A>G allele to be a risk factor for prostate cancer, whereas the 3801T>C status does not seem to be capable of modifying prostate cancer risk.

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Acknowledgments

The current study was financially supported by the Guangdong Natural Science Foundation (Grant No. S2011010004146).

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Authors and Affiliations

  1. Department of Nutrition and Food Hygiene, School of Public Health, Guangdong Medical College, No. 1 Xincheng Road, Dongguan, 523808, China

    Huawen Li

  2. Department of Clinical Biochemistry, School of Laboratory Medicine, Guangdong Medical College, No. 1 Xincheng Road, Dongguan, 523808, China

    Deqian Xiao

  3. Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Medical College, No. 2 Wenming Road, Zhanjiang, 524023, China

    Liren Hu

  4. Department of Nutrition and Food Hygiene, School of Public Health, Guangdong Medical College, No. 2 Wenming Road, Zhanjiang, 524023, China

    Taiping He

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  1. Huawen Li
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  2. Deqian Xiao
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Correspondence to Taiping He.

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Huawen Li and Deqian Xiao have contributed equally to this work.

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Li, H., Xiao, D., Hu, L. et al. Association of CYP1A1 polymorphisms with prostate cancer risk: an updated meta-analysis. Mol Biol Rep 39, 10273–10284 (2012). https://doi.org/10.1007/s11033-012-1904-5

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  • DOI: https://doi.org/10.1007/s11033-012-1904-5

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