Skip to main content
SpringerLink
Log in

Isolation and Characterization of Ubiquitin-activating Enzyme E1-domain Containing 1, UBE1DC1

  • Published:
Molecular Biology Reports Aims and scope Submit manuscript

Abstract

Ubiquitin and other ubiquitin-like proteins play important roles in post-translational modification. They are phylogenetically well-conserved in eukaryotes. Activated by other proteins, ubiquitin and ubiquitin-like proteins can covalently modify target proteins. The enzymes responsible for the activation of this modification have been known to include UBA1, SAE2, UBA3, SAE1 and ULA1. Here we report a new ubiquitin activating enzyme like cDNA, named ubiquitin activating enzyme E1-domain containing 1 (UBE1DC1), whose cDNA is 2654 base pairs in length and contains an open reading frame encoding 404 amino acids. The UBE1DC1 gene consists of 12 exons and is located at human chromosome 3q22. The result of RT-PCR showed that UBE1DC1 is expressed in most of human tissues.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

UBE1DC1:

ubiquitin-activating enzyme E1-domain containing 1

Ubls:

ubiquitin-like modifiers

References

  1. H Mark (2000) Nat. Cell Biol. 2 E206

    Google Scholar 

  2. M Hochstrasser (1996) Annu. Rev. Genet. 30 405–439 Occurrence Handle10.1146/annurev.genet.30.1.405 Occurrence Handle8982460 Occurrence Handle1:CAS:528:DyaK2sXht1yk

    Article  PubMed  CAS  Google Scholar 

  3. HM William SI Keisuke S Randi P Milena P Frank (2003) Oncogene 22 5755–5773

    Google Scholar 

  4. AL Haas TJ Siepmann (1997) FASEBJ. 11 1257–1268 Occurrence Handle1:CAS:528:DyaK2sXnvVKksrs%3D

    CAS  Google Scholar 

  5. M Hochstrasser (1998) Genes Dev. 12 901–907 Occurrence Handle9531529 Occurrence Handle1:CAS:528:DyaK1cXislygu7g%3D

    PubMed  CAS  Google Scholar 

  6. A Verger J Perdomo M Crossley (2003) EMBO Rep. 4 137–142 Occurrence Handle10.1038/sj.embor.embor738 Occurrence Handle12612601 Occurrence Handle1:CAS:528:DC%2BD3sXhslSqtLg%3D

    Article  PubMed  CAS  Google Scholar 

  7. K Kim S Baek C Chung (2002) J. Cell Physiol. 191 257–68 Occurrence Handle10.1002/jcp.10100 Occurrence Handle12012321 Occurrence Handle1:CAS:528:DC%2BD38XjsFGmsL8%3D

    Article  PubMed  CAS  Google Scholar 

  8. A Hershko A Ciechanoer (1998) Annu. Rev. Biochem. 67 425–479 Occurrence Handle10.1146/annurev.biochem.67.1.425 Occurrence Handle9759494 Occurrence Handle1:CAS:528:DyaK1cXlsFOmsLc%3D

    Article  PubMed  CAS  Google Scholar 

  9. A Ciechanover S Elias H Heller A Hershko (1982) J. Biol. Chem. 257 2537–2542 Occurrence Handle6277904 Occurrence Handle1:CAS:528:DyaL38Xhtlylu7s%3D

    PubMed  CAS  Google Scholar 

  10. AL Haas IA Rose (1982) J. Biol. Chem. 257 10329–10337 Occurrence Handle6286650 Occurrence Handle1:CAS:528:DyaL3sXmslygsA%3D%3D

    PubMed  CAS  Google Scholar 

  11. MA Read et al. (2000) Mol. Cell Biol. 20 2326–2333 Occurrence Handle10.1128/MCB.20.7.2326-2333.2000 Occurrence Handle10713156 Occurrence Handle1:CAS:528:DC%2BD3cXhvFegtbw%3D

    Article  PubMed  CAS  Google Scholar 

  12. D Liakopoulos G Doenges K Matuschewski S Jentsch (1998) EMBO J. 17 2208–2214 Occurrence Handle10.1093/emboj/17.8.2208 Occurrence Handle9545234 Occurrence Handle1:CAS:528:DyaK1cXivFOmsb4%3D

    Article  PubMed  CAS  Google Scholar 

  13. MPD Joana SR Manuel DK Graham TH Ronald (1999) J. Biol. Chem. 274 10618–10624

    Google Scholar 

  14. PM Hatfield RD Vierstra (1992) J. Biol. Chem. 267 14799–14803 Occurrence Handle1634524 Occurrence Handle1:CAS:528:DyaK3sXisFSmsb4%3D

    PubMed  CAS  Google Scholar 

  15. J Goodship H Gill J Carter A Jackson M Splitt M Wright (2000) Am. J. Hum. Genet. 67 498–503 Occurrence Handle10.1086/303023 Occurrence Handle10889046 Occurrence Handle1:CAS:528:DC%2BD3cXntVyqsbw%3D

    Article  PubMed  CAS  Google Scholar 

  16. P Amati P Gasparini J Zlotogora L Zelante JC Chomel A Kitzis J Kaplan D Bonneau (1996) Am. J. Hum. Genet. 58 1089–1092 Occurrence Handle8651270 Occurrence Handle1:STN:280:BymB3Mnhs1U%3D

    PubMed  CAS  Google Scholar 

  17. N Arsic T Rajic S Stanojcic PN Goodfellow M Stevanovic (1998) Cytogenet. Cell Genet. 83 139–146 Occurrence Handle10.1159/000015149 Occurrence Handle9925951 Occurrence Handle1:CAS:528:DyaK1MXhsFSit7w%3D

    Article  PubMed  CAS  Google Scholar 

  18. H Omran G Sasmaz K Haffner H Volz Olbrich R Melkaoui E Otto TF Wienker R Korinthenberg M Brandis C Antignac F Hildebrandt (2002) J. Am. Soc. Nephrol. 13 75–79 Occurrence Handle11752023 Occurrence Handle1:CAS:528:DC%2BD38XltV2htA%3D%3D

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, 200433, People’s Republic of China

    Tonghai Dou, Shaohua Gu, Jianping Liu, Fei Chen, Li Zeng, Lingchen Guo, Yi Xie & Yumin Mao

Authors
  1. Tonghai Dou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shaohua Gu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jianping Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Fei Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Li Zeng
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Lingchen Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yi Xie
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yumin Mao
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yumin Mao.

Additional information

These two authors contributed equally to this paper.

The nucleotide sequence reported in this paper has been submitted to GenBank under accession number AY253672.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dou, T., Gu, S., Liu, J. et al. Isolation and Characterization of Ubiquitin-activating Enzyme E1-domain Containing 1, UBE1DC1. Mol Biol Rep 32, 265–271 (2005). https://doi.org/10.1007/s11033-005-4822-y

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11033-005-4822-y

Keywords

Search

Navigation