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Magnetically recoverable Fe3O4 nanocatalyst for the synthesis of biodynamically significant 1H-pyrazolo[1,2-b]phthalazine-5,10-diones derivatives and its DFT study

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Abstract

An environmentally sustainable and proficient method is reported for the synthesis of medicinally important pyrazolo[1,2-b] phthalazine dione derivatives by aqueous micellar medium catalysed by Fe3O4 NPs. Dialkyl acetylenedicarboxylate with isocyanides in the presence of phthalhydrazide is used as starting material. The main advantages of this protocol are the availability of starting materials, short reaction times, green solvents and practical simplicity.

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Acknowledgements

The authors gratefully acknowledge SAIF, Punjab University Chandigarh, for providing all the spectroscopic and analytical data. M.D. Ansari acknowledges CSTUP (Project sanction letter No. CST/D- 2276) for the financial support. N. Yadav is grateful to CSIR, New Delhi, and Ankit Verma acknowledges UGC, New Delhi, for the Senior Research Fellowship (SRF). Manjit Singh acknowledged to IIT (BHU) for research fellowship. I also acknowledge Dr. Sonam Shakya, Department of Chemistry, Aligarh Muslim University, for providing the DFT studies.

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Authors and Affiliations

  1. Laboratory of Green Synthesis, Department of Chemistry, University of Allahabad, Allahabad, 211002, India

    Mohd Danish Ansari, Vijay B. Yadav, Neetu Yadav, Ankit Verma & I. R. Siddiqui

  2. Department of Chemistry, Paliwal P.G. College, Shikohabad, 205135, India

    Hozeyfa Sagir

  3. Department of Chemistry, Aligarh Muslim University, Aligarh, India

    Sonam Shakya

  4. Department of Chemistry, IIT BHU, Varanasi, India

    Manjit Singh

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  1. Mohd Danish Ansari
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Ansari, M.D., Sagir, H., Yadav, V.B. et al. Magnetically recoverable Fe3O4 nanocatalyst for the synthesis of biodynamically significant 1H-pyrazolo[1,2-b]phthalazine-5,10-diones derivatives and its DFT study. Mol Divers 27, 1853–1866 (2023). https://doi.org/10.1007/s11030-022-10532-3

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