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A synthesis of functionalized 3-amino-1,2,4-triazoles from nitrile imines and guanidine derivatives

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Abstract

A regioselective synthesis of trisubstituted 1,2,4-triazoles through reaction of nitrile imines with guanidine derivatives is described. These 1,3-dipolar cycloaddition reactions proceeded smoothly in moderate to good yields and excellent regioselectivity under ambient conditions. This method provides fast access to a range of functionalized 3-amino-1,2,4-triazoles.

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Acknowledgements

We thank the Research Council of Tarbiat Modares University for supporting this work.

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Authors and Affiliations

  1. Department of Chemistry, Tarbiat Modares University, PO Box 14115-175, Tehran, Iran

    Issa Yavari, Zohreh Taheri & Sara Sheikhi

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  1. Issa Yavari
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  2. Zohreh Taheri
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  3. Sara Sheikhi
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Correspondence to Issa Yavari.

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Yavari, I., Taheri, Z. & Sheikhi, S. A synthesis of functionalized 3-amino-1,2,4-triazoles from nitrile imines and guanidine derivatives. Mol Divers 28, 11–18 (2024). https://doi.org/10.1007/s11030-022-10471-z

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