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Heterogeneous catalyst SiO2–LaCl3·7H2O: characterization and microwave-assisted green synthesis of α-aminophosphonates and their antimicrobial activity

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Abstract

Silica-supported lanthanum (III) chloride (SiO2–LaCl3·7H2O) was prepared and characterized by infrared spectroscopy, X-ray diffraction analysis, scanning electron microscope, energy-dispersive X-ray spectroscopy, thermogravimetric analysis and differential thermal analysis techniques. The catalytic activity of this silica-supported lanthanum (III) chloride was investigated in a one-pot three-component Kabachnik-Fields reaction. A library of new α-aminophosphonates was prepared employing various benzothiazole and thiadiazole amines, different substituted aldehydes and diethylphosphite under solvent-free conditions using conventional/microwave methods with good to excellent yields (85–97%). The advantages of this catalyst are that it is environmentally benign, economically inexpensive, and easy to prepare, gives high yields and high purity is less time-consuming, offers easy purification is reusable and enables products to be obtained by simple recrystallization without column chromatography.

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Acknowledgments

The author, SK. Thaslim Basha expresses a deep sense of gratitude to University Grant Commission for awarding SRF and financial support. The authors also thank IIT Madras for providing spectroscopic and analytical data. This work was also supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea government (NRF-2019R1A2C1003735 and NRF-2020R1A6A1A03043435).

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Authors and Affiliations

  1. Organic Division, Department of Chemistry, Sri Venkateswara University, Tirupati, 517 502, India

    S. K. Thaslim Basha, H. Sudhamani & Chamarthi Naga Raju

  2. Department of Science and Humanities, Sri Venkateswara Engineering College, Karakambadi Road, Tirupati, Andhra Pradesh, 517507, India

    Reddi Mohan Naidu Kalla

  3. Centre of Applied Sciences, Department of Basic Sciences and Humanities, Sree Vidyanikethan Engineering College, A. Rangampet, Tirupati, Andhra Pradesh, 517502, India

    M. Varalakshmi

  4. HMC, Department of Nanotechnology and Advanced Materials Engineering, Sejong University, 209 Neungdong-ro, Gwangjin-gu, Seoul, 143-747, Republic of Korea

    Rama Moorthy Appa & Sung Chul Hong

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  1. S. K. Thaslim Basha
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  7. Chamarthi Naga Raju
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Correspondence to Reddi Mohan Naidu Kalla, Sung Chul Hong or Chamarthi Naga Raju.

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Basha, S.K.T., Kalla, R.M.N., Varalakshmi, M. et al. Heterogeneous catalyst SiO2–LaCl3·7H2O: characterization and microwave-assisted green synthesis of α-aminophosphonates and their antimicrobial activity. Mol Divers 26, 2703–2715 (2022). https://doi.org/10.1007/s11030-021-10360-x

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