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Lemon juice catalyzed C–C bond formation via C–H activation of methylarene: a sustainable synthesis of chromenopyrimidines

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Abstract

An economical and proficient approach has been developed for the synthesis of chromenopyrimidines via three-component reaction of thiobarbituric acid/barbituric acid, methylarenes and dimedone/1,3-cyclohexanedione by using lemon juice as a natural, biodegradable catalyst and TBHP as an oxidant. This transformation involves metal-free C–C bond formation via C–H activation of methylarenes under mild reaction conditions.

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Acknowledgements

Authors are grateful to IIT (BHU) for financial assistance in the form of institute fellowship and CIFC, IIT (BHU) for instrumentation facilities.

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  1. Department of Chemistry, Indian Institute of Technology (BHU), Varanasi, U.P., 221005, India

    Savita Kumari, Sundaram Singh & Vandana Srivastava

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  1. Savita Kumari
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Correspondence to Sundaram Singh.

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Kumari, S., Singh, S. & Srivastava, V. Lemon juice catalyzed C–C bond formation via C–H activation of methylarene: a sustainable synthesis of chromenopyrimidines. Mol Divers 24, 717–725 (2020). https://doi.org/10.1007/s11030-019-09980-1

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