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Synthesis of N-heterocycles containing 1,5-disubstituted-1H-tetrazole via post-Ugi-azide reaction

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Abstract

Ugi-azide four-component reaction (UA-4CR) as development on Ugi four-component reaction (U-4CR) is the condensation reaction involving an aldehyde, an amine, an isocyanide, and an azide source. Nowadays, UA-4CR has been employed for the efficient and facile production of 1,5-disubstituted-1H-tetrazoles (1,5-DS-1H-Ts). Interestingly, the combination of 1,5-DS-1H-Ts with suitable post-transformations in a tandem manner results in the construction of various classes of heterocyclic compounds bearing 1,5-DS-1H-T moiety. This review aims to provide the application of diverse post-Ugi-azide reaction in the preparation of different N-heterocyclic compounds bearing 1,5-DS-1H-T such as substituted and fused 1,5-DS-1H-Ts.

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Acknowledgements

We are grateful for financial support from the Research Council of Alzahra University. MMH also appreciate the financial support granted by Iran National Science Foundation (INSF) under the given individual research chair.

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  1. Department of Chemistry, School of Sciences, Alzahra University, Vanak, Tehran, Iran

    Leyla Mohammadkhani & Majid M. Heravi

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Mohammadkhani, L., Heravi, M.M. Synthesis of N-heterocycles containing 1,5-disubstituted-1H-tetrazole via post-Ugi-azide reaction. Mol Divers 24, 841–853 (2020). https://doi.org/10.1007/s11030-019-09972-1

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