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Nucleophilic phenylation: a remarkable application of alkoxymethyltriphenylphosphonium salts

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Abstract

A new application of α-alkoxymethylphosphonium salts in the nucleophilic phenylation of carbonyl compounds is demonstrated. Phenylation of aldehydes, ketones and acyl halides were studied by employing α-alkoxymethyltriphenylphosphonium halides in the presence of lithium hydroxide.

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New application of α-alkoxymethyltriphenylphosphonium salts. Metal-free, mild and selective phenylation. Easy preparation and handling of the reagent.

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Acknowledgements

Authors are obliged to the Pakistan Science Foundation (PSF), Islamabad, for the support of this research project (P-US/Chem 427).

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Authors and Affiliations

  1. Department of Chemistry, University of Sargodha, Sargodha, 40100, Pakistan

    Zain Maqsood Cheema, Humaira Yasmeen Gondal & Abdul Rauf Raza

  2. H.E.J. Research Institute of Chemistry, ICCBS, University of Karachi, Karachi, 75270, Pakistan

    Ahmed Abbaskhan

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  1. Zain Maqsood Cheema
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Correspondence to Humaira Yasmeen Gondal.

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Cheema, Z.M., Gondal, H.Y., Raza, A.R. et al. Nucleophilic phenylation: a remarkable application of alkoxymethyltriphenylphosphonium salts. Mol Divers 24, 455–462 (2020). https://doi.org/10.1007/s11030-019-09966-z

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