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Aroyl and acyl cyanides as orthogonal protecting groups or as building blocks for the synthesis of heterocycles

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Abstract

α-Cyanoketones represent a synthetically attractive scaffold possessing bifunctional reactivity which enabled synthesis of a diversity of products. This involves reaction of nucleophiles with electrophilic carbonyl carbon performing an efficient and regioselective way to acylation reaction, cycloaddition of activated cyano function with dipolarophiles, metal-catalyzed cross-dehydrogenative coupling carbocyanation across C–C multiple bonds as well as hydrocyanation. This review provides the recent developments in the chemistry of α-cyanoketones which will be beneficial for researchers and scientists in such field.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Minia University, Minia, 61519, Egypt

    Kamal Usef Sadek, Ramadan Ahmed Mekheimer & Mohamed Abd-Elmonem

  2. Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt

    Mohamed Hilmy Elnagdi

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Sadek, K.U., Mekheimer, R.A., Abd-Elmonem, M. et al. Aroyl and acyl cyanides as orthogonal protecting groups or as building blocks for the synthesis of heterocycles. Mol Divers 23, 1065–1084 (2019). https://doi.org/10.1007/s11030-019-09915-w

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