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Synthesis of 3-heteroarylchromones via a photochemical reaction

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Abstract

The direct coupling of 3-iodochromen-4-ones with heteroaromatics has been achieved via a photochemical reaction. A variety of 3-heteroarylchromones was obtained in moderate to good yields from the corresponding 3-iodochromen-4-ones and heteroaromatics, such as pyrrole, furan, thiophene, and benzofuran. The reaction worked smoothly in acetonitrile under a mercury lamp without any additives, providing a catalyst- and base-free approach for the synthesis of 3-heteroarylchromones.

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Acknowledgments

This research was supported by the National Natural Science Foundation of China (No: 21372150), the Fundamental Research Funds for the Central Universities (No: GK261001095), and the Science and Innovation Funds of Graduate Programs of Shaanxi Normal University (No: 2009CXS013).

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Authors and Affiliations

  1. Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an, 710062, People’s Republic of China

    Qian Yang, Yun He, Tao Wang, Lingyu Zeng & Zunting Zhang

  2. School of Sciences, Xi‘an University of Technology, Xi’an, 710054, People’s Republic of China

    Qian Yang

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  1. Qian Yang
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  2. Yun He
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  3. Tao Wang
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  4. Lingyu Zeng
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  5. Zunting Zhang
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Correspondence to Zunting Zhang.

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Yang, Q., He, Y., Wang, T. et al. Synthesis of 3-heteroarylchromones via a photochemical reaction. Mol Divers 20, 9–16 (2016). https://doi.org/10.1007/s11030-015-9620-4

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