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An efficient strategy to syntheses of isoflavones

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Abstract

Isoflavones were synthesized by two steps in good yields, starting from commercially available 2-hydroxyacetophenones and benzene analogs. First, intermediate 3-(dimethylamino)-1-(2-hydroxyphenyl) prop-2-en-1-ones were obtained by the condensation of 2-hydroxyacetophenones and DMF-DMA in DMF with high yields. Second, isoflavones were synthesized by irradiation of 3-(dimethylamino)-1-(2-hydroxyphenyl)prop- 2-en-1-ones in the presence of iodine using benzene analogs as solvent under a mercury lamp.

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Acknowledgments

This research was supported by the National Natural Science Foundation of China (No. 21372150), the Fundamental Research Funds for the Central Universities (No. GK261001095), and the Science and Innovation Funds of Graduate Programs of Shaanxi Normal University (No. 2009CXS013).

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Authors and Affiliations

  1. Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an, 710062, People’s Republic of China

    Longzhu Liu, Qiuya Wang, Zunting Zhang, Qiong Zhang, Zichao Du, Dong Xue & Tingting Wang

  2. College of Chemistry and Life Science, WeiNan Normal University, Weinan, 714000, People’s Republic of China

    Qiuya Wang

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  1. Longzhu Liu
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  2. Qiuya Wang
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  3. Zunting Zhang
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Correspondence to Zunting Zhang.

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Liu, L., Wang, Q., Zhang, Z. et al. An efficient strategy to syntheses of isoflavones. Mol Divers 18, 777–785 (2014). https://doi.org/10.1007/s11030-014-9537-3

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  • DOI: https://doi.org/10.1007/s11030-014-9537-3

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