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\(\hbox {FeF}_{3}\) catalyzed cascade C–C and C–N bond formation: synthesis of differentially substituted triheterocyclic benzothiazole functionalities under solvent-free condition

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Abstract

A series of diverse polyfunctionalized triheterocyclic benzothiazoles were easily prepared in excellent yields via the Biginelli reaction of 2-aminobenzothiazole with substituted benzaldehydes and \(\upalpha \)-methylene ketones using \(\hbox {FeF}_{3}\) as an expeditious catalyst under solvent-free conditions. The protocol provides a practical and straightforward approach toward highly functionalized triheterocyclic benzothiazole derivatives in excellent yields. The reaction was conveniently promoted by \(\hbox {FeF}_{3}\) and the catalyst could be recovered easily after the reaction and reused without any loss of its catalytic activity. The advantageous features of this methodology are high atom economy, operational simplicity, shorter reaction time, convergence, and facile automation.

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Authors and Affiliations

  1. Department of Image Science and Engineering, Pukyong National University, Busan , 608-737, Republic of Korea

    Amol B. Atar & Yeon Tae Jeong

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  1. Amol B. Atar
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  2. Yeon Tae Jeong
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Correspondence to Yeon Tae Jeong.

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Atar, A.B., Jeong, Y.T. \(\hbox {FeF}_{3}\) catalyzed cascade C–C and C–N bond formation: synthesis of differentially substituted triheterocyclic benzothiazole functionalities under solvent-free condition. Mol Divers 18, 389–401 (2014). https://doi.org/10.1007/s11030-014-9506-x

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