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Ionic liquid-supported synthesis of piperazine derivatives as potential insecticides

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Abstract

With the purpose of extending our efforts on the search and synthesis of new insecticides with novel acting modes, a series of novel 4-(2-(4-(pyridin-2-yl)piperazin-1-yl)ethoxy)aniline derivatives were designed based on classical serotonin receptor ligands and synthesized through the rapid ionic liquid-supported parallel synthesis with yields up to 88 %. These products were purified through the convenient washing with appropriate solvents and isolated in good yield. In addition, 27 amide or urea derivatives of anilines were also prepared. Bioassay data showed that some of the synthesized compounds displayed selective insecticidal bioactivities against tested pests.

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Acknowledgments

Financial support for this study from the NSFC (Grant 20972052), National Basic Research Program of China (973 Program) (Grant 2010CB126101), and National Key Technology R and D Program (Grant No. 2011BAE06B05-4) are gratefully acknowledged.

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Authors and Affiliations

  1. Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai,  200237, China

    Yan Shen, Jia-Yi Wang & Gong-Hua Song

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  1. Yan Shen
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  2. Jia-Yi Wang
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  3. Gong-Hua Song
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Correspondence to Gong-Hua Song.

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Shen, Y., Wang, JY. & Song, GH. Ionic liquid-supported synthesis of piperazine derivatives as potential insecticides. Mol Divers 18, 195–202 (2014). https://doi.org/10.1007/s11030-013-9492-4

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