Abstract
A series of thiazoline-incorporated chalconoids, designed based on natural product scaffold, were efficiently synthesized via the reaction of 3-methyl-4-arylthiazole-2(3\(H\))-thiones and appropriate phenacyl halides, and subsequent desulfurization. The starting 3-methyl-4- arylthiazole-2(3\(H\))-thiones were also prepared from phenacyl halides. The structural aspects and (\(Z\))-geometry of compounds were confirmed by IR and \(^{1}\)H NMR spectral data. This chemistry provides a new library of compounds basically originated from phenacyl halides as building blocks, with potential activity for biomedical screening.
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This work was supported by a grant from the Research Council of Mazandaran University of Medical Sciences, Sari, Iran
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Ayati, A., Emami, S. Straightforward synthesis of thiazoline-incorporated chalconoids from phenacyl halides. Mol Divers 17, 41–47 (2013). https://doi.org/10.1007/s11030-012-9416-8
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DOI: https://doi.org/10.1007/s11030-012-9416-8