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Regioselective multi-component synthesis of 1H-pyrazolo[3,4-d]pyrimidine-6(7H)-thiones

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Abstract

A variety of pyrazolo[3,4-d]pyrimidine-6(7H)-thione derivatives were easily synthesized with a novel, simple, efficient, and regioselective method via three-component condensation reaction of 5-methyl-1H-pyrazol-3-amine, arylisothiocyanates, and aldehydes in the presence of catalytic amount of p-toluenesulfonic acid (p-TSA) in 1-butyl-3-methylimidazolium bromide ionic liquid with excellent yields and short reaction times.

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Authors and Affiliations

  1. Catalysis Division, Department of Chemistry, University of Isfahan, Isfahan, 81746-73441, Iran

    Shirin Safaei, Iraj Mohammadpoor-Baltork, Ahmad Reza Khosropour, Majid Moghadam, Shahram Tangestaninejad & Valiollah Mirkhani

Authors
  1. Shirin Safaei
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  2. Iraj Mohammadpoor-Baltork
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  3. Ahmad Reza Khosropour
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  4. Majid Moghadam
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  5. Shahram Tangestaninejad
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  6. Valiollah Mirkhani
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Correspondence to Iraj Mohammadpoor-Baltork or Ahmad Reza Khosropour.

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Safaei, S., Mohammadpoor-Baltork, I., Khosropour, A.R. et al. Regioselective multi-component synthesis of 1H-pyrazolo[3,4-d]pyrimidine-6(7H)-thiones. Mol Divers 16, 591–600 (2012). https://doi.org/10.1007/s11030-012-9391-0

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  • DOI: https://doi.org/10.1007/s11030-012-9391-0

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