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Reaction of isocyanides with thiophenols and gem-diactivated olefins: a one-pot synthesis of substituted 2-aminopyrroles

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Abstract

A novel multicomponent reaction of isocyanides with thiophenols and gem-diactivated olefins has been discovered. Depending on the choice of isocyanides, substituted 2-aminopyrroles or thioimidates have been prepared. The obtained scaffolds bearing four points of diversity can directly be used in combinatorial syntheses.

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Authors and Affiliations

  1. Department of Technology for Organic Synthesis (TOSLab), Ural State Technical University, 620002, Ekaterinburg, Russian Federation

    Anna N. Kolontsova, Maria N. Ivantsova, Maria I. Tokareva & Maxim A. Mironov

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  1. Anna N. Kolontsova
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  2. Maria N. Ivantsova
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  3. Maria I. Tokareva
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  4. Maxim A. Mironov
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Correspondence to Maxim A. Mironov.

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Kolontsova, A.N., Ivantsova, M.N., Tokareva, M.I. et al. Reaction of isocyanides with thiophenols and gem-diactivated olefins: a one-pot synthesis of substituted 2-aminopyrroles. Mol Divers 14, 543–550 (2010). https://doi.org/10.1007/s11030-010-9233-x

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  • DOI: https://doi.org/10.1007/s11030-010-9233-x

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