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Multicomponent reactions of dimethyl methoxymalonate and dialkyl acetylenedicarboxylate in the presence of N-Nucleophiles: one-pot synthesis of 2H-pyridinyl-2-butenedioates in water

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Abstract

An efficient synthesis of 2H-pyridinyl-2-butenedioate derivatives via reaction of dimethyl methoxymalonate and dialkyl acetylenedicarboxylate in the presence of N-nucleophiles in water as a solvent is described.

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Authors and Affiliations

  1. Chemistry Department, Islamic Azad University, Qaemshahr Branch, Mazandaran, Iran

    Mohammad A. Khalilzadeh, Zinatossadat Hossaini & Samaneh Kharian

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  1. Mohammad A. Khalilzadeh
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  2. Zinatossadat Hossaini
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  3. Samaneh Kharian
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Correspondence to Mohammad A. Khalilzadeh.

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Khalilzadeh, M.A., Hossaini, Z. & Kharian, S. Multicomponent reactions of dimethyl methoxymalonate and dialkyl acetylenedicarboxylate in the presence of N-Nucleophiles: one-pot synthesis of 2H-pyridinyl-2-butenedioates in water. Mol Divers 14, 605–609 (2010). https://doi.org/10.1007/s11030-009-9192-2

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  • DOI: https://doi.org/10.1007/s11030-009-9192-2

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