Abstract
The novel three-component reaction of isoquinoline with isothiocyanates and isocyanides leads to a variety of new imidazoisoquinolines. The zwitterionic ground state of these new ring systems is established by means of NMR and X-ray analysis. Use of phthalazine instead of isoquinoline gives access to imidazole annulated phthalazines.
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Mironov, M.A., Maltsev, S.S., Mokrushin, V.S. et al. A novel three-component reaction designed by the combinatorial method: Heteroarenes, isothiocyanates and isocyanides. Mol Divers 9, 221–227 (2005). https://doi.org/10.1007/s11030-005-2823-3
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DOI: https://doi.org/10.1007/s11030-005-2823-3