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Polyhydroquinolines: 1-sulfopyridinium chloride catalyzed an efficient one-pot multicomponent synthesis via Hantzsch condensation under solvent-free conditions

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Abstract

A simple and highly efficient method has been developed for the construction of polyhydroquinoline derivatives via one-pot, four-component Hantzsch condensation of various aldehydes, dimedone, ethyl acetoacetate, and ammonium acetate in the presence of an ionic liquid, 1-sulpopyridinium chloride, as a catalyst under solvent-free conditions. This methodology has an advantage of high yields, short reaction times, a clean reaction profile, and reusability of the catalyst.

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Acknowledgments

We gratefully acknowledge the head of the Department of Chemistry, Osmania University, for providing research facilities. One of the authors (B. Sonyanaik) thanks the University Grant Commission (UGC) New Delhi, India, for providing research fellowships.

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Authors and Affiliations

  1. Department of Chemistry, Osmania University, Hyderabad, Telangana State, 500007, India

    B. Sakram, B. Sonyanaik, K. Ashok & S. Rambabu

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  1. B. Sakram
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  2. B. Sonyanaik
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  3. K. Ashok
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  4. S. Rambabu
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Correspondence to B. Sakram.

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Sakram, B., Sonyanaik, B., Ashok, K. et al. Polyhydroquinolines: 1-sulfopyridinium chloride catalyzed an efficient one-pot multicomponent synthesis via Hantzsch condensation under solvent-free conditions. Res Chem Intermed 42, 7651–7658 (2016). https://doi.org/10.1007/s11164-016-2559-y

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