Abstract
Brain aging is a physiological event, and oxidative stress and apoptosis are involved in the natural aging process of the brain. Curcumin is a natural antioxidant with potent anti-aging and neuroprotective properties. Therefore, we investigated the protective effects of curcumin on brain apoptosis and oxidative stress, brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF) in aged rats. Old female Wistar rats were randomly divided into three groups (n = 7); as follows: (1) control; (2); saline and (3) curcumin (received 30 mg/kg of curcumin, 5 days/week for 8 weeks, intraperitoneally). Our results indicated that treatment with curcumin in aged rats attenuates brain lipid peroxidation, which was accompanied by a significant increase in the BDNF, VEGF, superoxide dismutase (SOD) activity, and anti-apoptotic protein BCl-2. No significant change in brain anti-apoptotic Bax protein levels was observed after curcumin treatment. The study indicates that curcumin could alleviate brain aging which may be due to attenuating oxidative stress, inhibiting apoptosis, and up-regulating SOD activity, which in turn enhances VEGF and BDNF. Therefore, curcumin has potential therapeutic value in the treatment of neurological apoptosis, neurogenesis, and angiogenesis changes caused by brain aging.
Highlights
Brain aging plays a key role in the development of neurodegenerative diseases.
Oxidative stress is considered one of the main mechanisms of cellular aging.
Brain tissue has relatively low levels of antioxidant enzymes and is more vulnerable to oxidative stress.
During the aging process, apoptosis and susceptibility to apoptosis enhance in several types of intact cells.
Age-related decline in vascular structural integrity and neovascularization capacity occurs throughout the aged brain.
Curcumin, exerts its neuroprotective and anti-aging effects in the aged brain.
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Abbreviations
- BDNF:
-
Brain-derived neurotrophic factor
- Bax:
-
BCL-2 associated x protein
- Bcl-2:
-
B cell leukemia/lymphoma 2
- DNA:
-
Deoxyribonucleic acid
- H2O2:
-
Hydrogen Peroxide
- Flk-1:
-
Fetal liver kinase-1
- i.p.:
-
Intraperitoneal
- NRF2:
-
NF-E2 p45-related factor 2
- ROS:
-
Reactive oxygen species
- SOD:
-
Superoxide dismutase
- TBARS:
-
Thiobarbituric acid reactive substances
- VEGF:
-
Vascular endothelial growth factor
- TGF-β1:
-
Transforming growth factor β1
- TrkB:
-
Tropomyosin receptor kinase B
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Thanks to the vice chancellor of research of Islamic Azad University, Qaemshahar Branch, Qaemshahar, Iran.
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A Part of this project was supported by Qaemshahar Branch, Islamic Azad University, Qaemshahar, Iran (project grant no. 1/15424).
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Cheriki, M., Habibian, M. & Moosavi, S.J. Curcumin attenuates brain aging by reducing apoptosis and oxidative stress. Metab Brain Dis (2024). https://doi.org/10.1007/s11011-023-01326-z
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DOI: https://doi.org/10.1007/s11011-023-01326-z