Abstract
Alzheimer’s disease (AD) is the most common cause of dementia. In recent years, several studies have robustly shown that neuroinflammation plays a crucial role in the pathophysiology of this disease. The co-localization of amyloid-β plaques near activated glial cells and the increased levels of inflammatory cytokines in AD patients indicate the involvement of the neuroinflammatory process in AD progression. Considering that pharmacological treatment remains a challenge for the management of this disease, compounds with anti-inflammatory and antioxidant properties are promising therapeutic strategies. In this context, vitamin D has gained attention in the last few years due to its neuroprotective property and the high prevalence of vitamin D deficiency in the population. Herein, in this narrative review we present the possible contribution of the antioxidant and anti-inflammatory properties of vitamin D for its neuroprotective effects, and the clinical and preclinical data dealing with the effects of vitamin D in AD, focusing mainly on the neuroinflammatory process.
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The authors acknowledge funding from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; #312215/2021-5 and #3421142/2018-5) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). ALSR is CNPq Research Fellow.
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Bruna R Kouba: Idea, preparation of manuscript and literature review.
Anderson Camargo: Editing and compilation.
Ana Lúcia S. Rodrigues: Idea, editing and literature review.
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Kouba, B.R., Camargo, A. & Rodrigues, A.L.S. Neuroinflammation in Alzheimer’s disease: potential beneficial effects of vitamin D. Metab Brain Dis 38, 819–829 (2023). https://doi.org/10.1007/s11011-023-01188-5
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DOI: https://doi.org/10.1007/s11011-023-01188-5