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Resveratrol protects the brain against oxidative damage in a dopaminergic animal model of mania

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Abstract

The present study aimed to evaluate the effects of resveratrol on behavior and oxidative stress parameters in the brain of rats submitted to the animal model of mania induced by m-AMPH. In the first model (reversal treatment), rats received intraperitoneal (i.p.) injection of saline or m-AMPH (1 mg/kg body weight) once a day for 14 days, and from the 8th to the 14th day, they were orally treated with water or resveratrol (15 mg/kg), once a day. In the second model (maintenance treatment), rats were orally pretreated with water or resveratrol (15 mg/kg) once a day, and from the 8th to the 14th day, they received saline or m-AMPH i.p., once a day. Locomotor and exploratory activities were assessed in the open-field test. Oxidative and nitrosative damage parameters to lipid and proteins were evaluated by TBARS, 4-HNE, carbonyl, and 3-nitrotyrosine in the brain submitted to the experimental models. m-AMPH administration increased the locomotor and exploratory activities; resveratrol was not able to reverse or prevent these manic-like behaviors. Additionally, m-AMPH increased the lipid and protein oxidation and nitrosylation in the frontal cortex, hippocampus, and striatum of rats. However, resveratrol prevented and reversed the oxidative and nitrosative damage to proteins and lipids in all cerebral areas assessed. Since oxidative stress plays an important role in BD pathophysiology, supplementation of resveratrol in BD patients could be regarded as a possible adjunctive treatment with mood stabilizers.

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Acknowledgements

This study was in part funded by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES - Finance Code 001), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina (FAPESC), Instituto Cérebro e Mente and Universidade do Extremo Sul Catarinense (UNESC). JQ and SSV are CNPq Research Fellows. GCD, JHC and SM are holder of a FAPESC studentship and FFG is holder of a CNPq studentship.

Funding

“This study was funded in part by the following brazillian institutions: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) - Finance Code 001”, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina (FAPESC), Instituto Cérebro e Mente and Universidade do Extremo Sul Catarinense (UNESC), and Associação Fundo de Incetivo à Pesquisa (AFIP).   

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Authors and Affiliations

  1. Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil

    Samira Menegas, Camila L. Ferreira, José Henrique Cararo, Fernanda F. Gava, Gustavo C. Dal-Pont, João Quevedo & Samira S. Valvassori

  2. Experimental Neurology Laboratory, Graduate Program in Health Sciences, University of SouthernSanta Catarina (UNESC), Criciúma, SC, Brazil

    Maria L. Gomes & Jotele F. Agostini

  3. Laboratory of Inborn Errors of Metabolism, School of Sciences, Pontifical Catholic University of RioGrande do Sul, Porto Alegre, RS, USA

    Patrícia Fernanda Schuck

  4. Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA

    Giselli Scaini & João Quevedo

  5. Department of Psychobiology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil

    Monica L. Andersen

  6. Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA

    João Quevedo

  7. Neuroscience Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA

    João Quevedo

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  1. Samira Menegas
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  2. Camila L. Ferreira
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  3. José Henrique Cararo
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  6. Maria L. Gomes
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  9. Giselli Scaini
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  10. Monica L. Andersen
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  11. João Quevedo
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  12. Samira S. Valvassori
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Correspondence to Samira S. Valvassori.

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Conflict of interest

João Quevedo has the following conflicts of interest:

I. Clinical Research Support: Janssen Pharmaceutical (Clinical Trial), Allergan (Clinical Trial)

II. Advisory Boards, Speaker Bureaus, Expert Witness, or Consultant: Daiichi Sankyo (Speaker Bureau)

III. Patent, Equity, or Royalty: Instituto de Neurociencias Dr. Joao Quevedo (Stockholder)

IV. Other: Artmed Editora (Copyright), Artmed Panamericana (Copyright)

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Menegas, S., Ferreira, C.L., Cararo, J.H. et al. Resveratrol protects the brain against oxidative damage in a dopaminergic animal model of mania. Metab Brain Dis 34, 941–950 (2019). https://doi.org/10.1007/s11011-019-00408-1

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