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Effect of coenzyme Q10 supplementation on diabetes induced memory deficits in rats

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Abstract

The main objective of current work was to determine the effects of low and high dose supplementation with coenzyme Q10 (CoQ10) on spatial learning and memory in rats with streptozotocin (STZ)-induced diabetes. Male Wistar rats (weighing 220 ± 10) were randomly divided into six groups: (i) Control (Con, n = 8); (ii) Control+ Low dose of CoQ10 (100 mg/kg) (CLD, n = 10); (iii) Control+ high dose of CoQ10 (600 mg/kg) (CHD, n = 10); (iv) Diabetic (D, n = 10); (v) Diabetic + Low dose of CoQ10 (100 mg/kg) (DLD, n = 10); (vi) Diabetic + high dose of CoQ10 (600 mg/kg) (DHD, n = 10). Diabetes was induced by a single intraperitoneal injection of 50 mg/kg STZ. CoQ10 was administered intragastrically by gavage once a day for 90 days. After 90 days, Morris water maze (MWM) task was used to evaluate the spatial learning and memory in rats. Diabetic animals showed a slower rate of acquisition with respect to the control animals [F (1, 51) = 92.81, P < 0.0001, two-way ANOVA]. High dose (but no low dose) supplementation with CoQ10 could attenuate deteriorative effect of diabetes on memory acquisition. Diabetic animals which received CoQ10 (600 mg/kg) show a considerable decrease in escape latency and traveled distance compared to diabetic animals (p < 0.05, two-way ANOVA,). The present study has shown that low dose supplementation with CoQ10 in diabetic rats failed to improve deficits in cognitive function but high dose supplementation with CoQ10 reversed diabetes-related declines in spatial learning.

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Acknowledgements

The authors would like to express their gratitude to the staff of the Neurophysiology Research Center for helping us to carry out this project. This research was supported by a grant (grant number: IR.UMSHA.REC.1394.360) of the Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

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  1. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

    Ghazaleh Omidi, Seyed Asaad Karimi, Arezoo Rezvani-Kamran, Amirreza Monsef, Siamak Shahidi & Alireza Komaki

  2. Department of Neuroscience, School of Advanced Technologies in Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

    Seyed Asaad Karimi, Siamak Shahidi & Alireza Komaki

  3. Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Shahid Fahmideh Street, Hamadan, 65178/518, Iran

    Alireza Komaki

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  1. Ghazaleh Omidi
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Omidi, G., Karimi, S.A., Rezvani-Kamran, A. et al. Effect of coenzyme Q10 supplementation on diabetes induced memory deficits in rats. Metab Brain Dis 34, 833–840 (2019). https://doi.org/10.1007/s11011-019-00402-7

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