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IgM-mediated autoimmune responses to oxidative specific epitopes, but not nitrosylated adducts, are significantly decreased in pregnancy: association with bacterial translocation, perinatal and lifetime major depression and the tryptophan catabolite (TRYCAT) pathway

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Abstract

Immunoglubulin (Ig)M responses directed to oxidative specific epitopes (OSEs) and nitric oxide (NO)-adducts are significantly associated with major depression and physio-somatic symptoms. End of term serum IgM responses to OSEs and NO-adducts were assayed in pregnant women with (n = 24) and without prenatal depression (n = 25) as well as in 24 non-pregnant women. Associations of IgM/IgA responses to Gram-negative gut commensal bacteria (leaky gut index) and IgA/IgM responses to tryptophan catabolites (TRYCATs) were analyzed. IgM responses to OSEs, but not NO-adducts, were significantly reduced at the end of term. There were no significant associations between IgM responses to OSEs and perinatal depression, whilst IgM responses to NO-adducts, especially NO-cysteinyl, were significantly associated with a lifetime major depression. IgM responses to OSEs and NO-cysteinyl were significantly associated with IgA/IgM responses to Gram-negative bacteria, especially Morganella morganii, Klebsiella pneumoniae and Citrobacter koseri. IgM responses to NO-adducts and OSEs, especially malondialdehyde and myristic acid, and C-reactive protein (CRP) were inversely associated with TRYCAT pathway activity, whilst a lifetime depression and Pseudomonas putida were positively associated. The attenuation of natural IgM-mediated responses to OSEs at the end of term may indicate lowered activity of this part of the compensatory (anti-)inflammatory reflex system and may be partly explained by lowered bacterial translocation. Increased IgM responses to NO-cysteinyl is a biomarker of lifetime depression and may be induced by bacterial translocation. Natural IgM-mediated autoimmune responses, increased nitrosylation and higher CRP levels may have negative regulatory effects on the TRYCAT pathway.

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Acknowledgements

This research has been supported by the Ratchadaphiseksomphot Endowment Fund 2013 of Chulalongkorn University (CU-56-457-HR) and IDRPHT, Talence, France.

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Authors and Affiliations

  1. Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

    Chutima Roomruangwong, Buranee Kanchanatawan & Michael Maes

  2. Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

    Sunee Sirivichayakul

  3. CRC Scotland & London, London, UK

    George Anderson

  4. Department of Clinical Medicine and Translational Psychiatry Research Group, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil

    André F. Carvalho

  5. Research Department, IDRPHT, Talence, France

    Sebastien Duleu & Michel Geffard

  6. GEMAC, Lieu-Dit Berganton, Saint Jean d‘Illac, France

    Michel Geffard

  7. Department of Psychiatry, Faculty of Medicine, State University of Londrina, Londrina, Brazil

    Michael Maes

  8. Department of Psychiatry, Medical University Plovdiv, Plovdiv, Bulgaria

    Michael Maes

  9. Revitalis, Waalre, The Netherlands

    Michael Maes

  10. IMPACT Research Center, Barwon Health, Deakin University, Geelong, VIC, Australia

    Michael Maes

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  1. Chutima Roomruangwong
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  2. Buranee Kanchanatawan
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  8. Michael Maes
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Contributions

CR and MM made the design of the study. Participants were recruited and screened by CR. Biomarker assays were performed by MG and SD. All authors contributed equally to the writing up of the paper. All authors agreed upon the final version of the paper.

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Correspondence to Michael Maes.

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Roomruangwong, C., Kanchanatawan, B., Sirivichayakul, S. et al. IgM-mediated autoimmune responses to oxidative specific epitopes, but not nitrosylated adducts, are significantly decreased in pregnancy: association with bacterial translocation, perinatal and lifetime major depression and the tryptophan catabolite (TRYCAT) pathway. Metab Brain Dis 32, 1571–1583 (2017). https://doi.org/10.1007/s11011-017-0040-2

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