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The mechanisms of exercise improving cardiovascular function by stimulating Piezo1 and TRP ion channels: a systemic review

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Abstract

Mechanosensitive ion channels are widely distributed in the heart, lung, bladder and other tissues, and plays an important role in exercise-induced cardiovascular function promotion. By reviewing the PubMed databases, the results were summarized using the terms “Exercise/Sport”, “Piezo1”, “Transient receptor potential (TRP)” and “Cardiovascular” as the keywords, 124-related papers screened were sorted and reviewed. The results showed that: (1) Piezo1 and TRP channels play an important role in regulating blood pressure and the development of cardiovascular diseases such as atherosclerosis, myocardial infarction, and cardiac fibrosis; (2) Exercise promotes cardiac health, inhibits the development of pathological heart to heart failure, regulating the changes in the characterization of Piezo1 and TRP channels; (3) Piezo1 activates downstream signaling pathways with very broad pathways, such as AKT/eNOS, NF-κB, p38MAPK and HIPPO-YAP signaling pathways. Piezo1 and Irisin regulate nuclear localization of YAP and are hypothesized to act synergistically to regulate tissue mechanical properties of the cardiovascular system and (4) The cardioprotective effects of exercise through the TRP family are mostly accomplished through Ca2+ and involve many signaling pathways. TRP channels exert their important cardioprotective effects by reducing the TRPC3-Nox2 complex and mediating Irisin-induced Ca2+ influx through TRPV4. It is proposed that exercise stimulates the mechanosensitive cation channel Piezo1 and TRP channels, which exerts cardioprotective effects. The activation of Piezo1 and TRP channels and their downstream targets to exert cardioprotective function by exercise may provide a theoretical basis for the prevention of cardiovascular diseases and the rehabilitation of clinical patients.

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Funding

This work was supported by National Natural Science Foundation of China Grants (31900828 to Y.X. and 32171128 to Z.T.) and the Fundamental Research Funds for the Central Universities (GK202301013 to Y.X.).

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  1. Institute of Sports and Exercise Biology, Shaanxi Normal University, Xi’an, 710119, China

    Xinyan Duan, Renhan Liu, Yue Xi & Zhenjun Tian

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XD, YX and ZT established the theme of the review and constructed the framework; XD and YX searched the papers and did analysis; XD, RL and YX drafted manuscript; XD and YX prepared the figures; XD, RL, YX and ZT revised manuscript and approved the final version.

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Duan, X., Liu, R., Xi, Y. et al. The mechanisms of exercise improving cardiovascular function by stimulating Piezo1 and TRP ion channels: a systemic review. Mol Cell Biochem (2024). https://doi.org/10.1007/s11010-024-05000-5

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