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Effect of IL-10 in the pathogenesis of HIV/AIDS patients with cryptococcal meningitis

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Abstract

This study aimed to explore the role of IL-10 in the pathogenesis of HIV/AIDS patients with cryptococcal meningitis (CM).Patients were assigned into 4 groups (n = 40/group): group A (HIV/AIDS with CM), group B (HIV/AIDS with tuberculosis), group C (HIV/AIDS), and group D (CM). The levels of IL-10 and associated indicators were measured and the correlations were analyzed by Pearson correlation and partial correlation method. In plasma and cerebrospinal fluid (CSF), no significant difference was observed on IL-10 level between group A and other groups (P > 0.050). R values for IL-10 and relevant indicators in blood were as follows (P < 0.050): group A, IFN-γ (−0.377), IL-12 (0.743), IL-4 (0.881), and IL-6 (0.843); group B, IL-12 (0.740), IL-4 (0.573), and IL-6 (0.900); group C, IL-12 (0.402) and IL-4 (0.896); group D, IL-12 (0.575), IL-4 (0.852), and CD8 (0.325). R values for IL-10 and related indicators in CSF were as follows (P < 0.050): group A, TNF-α (0.664), IL-4 (0.852), white blood cells (WBCs, 0.321) and total protein (TP, 0.330); group B, TNF-α (0.566), IL-4 (0.702), and lactate dehydrogenase (LDH, 0.382); group D, IFN-γ (0.807) and IL-4 (0.441). IL-10 level was positively correlated with IL-4, IL-6, IL-12, TNF-α, WBC, and TP in blood or CSF, and negatively correlated with IFN-γ in blood, suggesting that IL-10 affected both pro-inflammatory and anti-inflammatory activities in the pathogenesis of HIV/AIDS with CM.

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Funding

This research was supported by the self-funded scientific research project of Guangxi Health Commission (Grant No. Z2016067) and the key research and developmental project of Nanning science and technology bureau (Grant No. 20193008-2).

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  1. Lida Mo and Guosheng Su are co-first authors.

Authors and Affiliations

  1. Department of Laboratory Medicine, Nanning Fourth People’s Hospital, Guangxi AIDS Clinical Treatment Center (Nanning), Nanning Infectious Disease Hospital Affiliated to Guangxi Medical University, Nanning, 530023, China

    Lida Mo, Hanzhen Su, Wanhong Huang & Xiaolu Luo

  2. Department of Laboratory Medicine, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Wuhou District, Chengdu, 610041, Sichuan, China

    Guosheng Su & Chuanmin Tao

  3. Department of Laboratory Medicine, People’s Hospital of Guangxi-ASEAN Economic and Technological Development Zone, The Tenth People’s Hospital of Nanning, Nanning, 530105, Guangxi, China

    Guosheng Su

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  1. Lida Mo
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Mo, L., Su, G., Su, H. et al. Effect of IL-10 in the pathogenesis of HIV/AIDS patients with cryptococcal meningitis. Mol Cell Biochem 478, 1–11 (2023). https://doi.org/10.1007/s11010-022-04488-z

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