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The roles of microRNAs played in lung diseases via regulating cell apoptosis

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Abstract

MicroRNAs (miRNAs) are a type of endogenous non-coding short-chain RNA, which plays a crucial role in the regulation of many essential cellular functions, including cellular migration, proliferation, invasion, autophagy, oxidative stress, apoptosis, and differentiation. The lung can be damaged by pathogenic microorganisms, as well as physical or chemical factors. Research has confirmed that miRNAs and lung cell apoptosis can affect the development and progression of several lung diseases. This article reviews the role of miRNAs in the development of lung disease through regulating host cell apoptosis.

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Acknowledgements

This work was supported by the Natural Science Foundation of Hunan Province (2020JJ4527, 2019JJ50494), the Scientific Research Fund of Hunan Provincial Education Department (20A438) and the Fund of Hunan Key Laboratory (2019TP1027).

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Authors and Affiliations

  1. Department of Public Health Laboratory Sciences, College of Public Health, Hengyang Medical School, University of South China, 28 West Changsheng Rd, Hengyang, 421001, Hunan, China

    Qiaoling Huang, Li Chen, Qinqin Bai, Ting Tong, You Zhou & Lili Chen

  2. Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, College of Public Health, University of South China, 28 West Changsheng Rd, Hengyang, 421001, Hunan, China

    Qiaoling Huang, Li Chen, Qinqin Bai, Ting Tong, You Zhou & Lili Chen

  3. Hengyang Medical School, University of South China, 28 West Changsheng Rd, Hengyang, 421001, Hunan, China

    Zhongyu Li, Chunxue Lu & Shenghua Chen

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  1. Qiaoling Huang
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  2. Li Chen
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  3. Qinqin Bai
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  8. Shenghua Chen
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  9. Lili Chen
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Contributions

QH had the idea for the article and drafted the manuscript. QH, LC, QB, TT, YZ, ZL and CL performed the literature search and revised the manuscript. LC and SC critically revised the manuscript. All authors read and approved the final manuscript.

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Correspondence to Shenghua Chen or Lili Chen.

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Huang, Q., Chen, L., Bai, Q. et al. The roles of microRNAs played in lung diseases via regulating cell apoptosis. Mol Cell Biochem 476, 4265–4275 (2021). https://doi.org/10.1007/s11010-021-04242-x

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