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Lipid metabolites and their differential pro-arrhythmic profiles: of importance in the development of a new anti-arrhythmic pharmacology

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Abstract

Arrhythmias have been treated for a long time with drugs that mainly target the ionic pumps and channels. These anti-arrhythmic regimens per se introduce new arrhythmias, which can be detrimental to patients. Advances in development of novel pharmacology without introduction of iatrogenic arrhythmias are thus favorable for an effective treatment of arrhythmias. Electrophysiological stability of the heart has been shown to be closely associated with cardiac metabolism. The present effective anti-arrhythmic drugs such as beta-blockers and amiodarone have profound beneficial effects in regulating myocardial metabolism. Aiming at decreasing production of toxic metabolites or preventing accumulation of arrhythmogenic lipids perhaps is a good strategy to effectively control arrhythmias. Therefore, a better understanding of the pro-arrhythmic profiles of cardiac metabolites helps to explore a new generation of metabolically oriented anti-arrhythmic medications. In this review, we present several lipid metabolites and summarize their arrhythmogenic characteristics.

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Acknowledgments

This work is supported by AFA insurance, the Swedish Heart and Lung Foundation, the Swedish Scientific Research Council and the University of Gothenburg, Sweden.

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Authors and Affiliations

  1. Department of Molecular and Clinical Medicine, Sahlgrenska Academy at University of Gothenburg, Bruna stråket 16, 413 45, Gothenburg, Sweden

    Yangzhen Shao, Bjorn Redfors, Sigfus Gizurarson & Elmir Omerovic

  2. Inserm U1045 Centre de Recherche Cardio-Thoracique, L’Institut de Rythmologie et modélisation Cardiaque (LIRYC), Université de Bordeaux, Bordeaux, France

    David Benoist

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  1. Yangzhen Shao
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Correspondence to Yangzhen Shao.

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Shao, Y., Redfors, B., Benoist, D. et al. Lipid metabolites and their differential pro-arrhythmic profiles: of importance in the development of a new anti-arrhythmic pharmacology. Mol Cell Biochem 393, 191–197 (2014). https://doi.org/10.1007/s11010-014-2060-0

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