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The effect of fat intake and antihypertensive drug therapy on serum lipid profile: a cross-sectional survey of serum lipids in male and female hypertensives

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Abstract

The present study aimed to investigate the effect of betablocker with diuretics therapy on serum cholesterol and high density lipoprotein (HDL-C) lipids in cross-sectional data (age, sex, weight, and body mass index (BMI), smoking/alcoholic consumption) and supplemented vegetarian low-fat diet with daily low fat energy intake, salt intake, duration of drug therapy, and serum protein as effective measures of lowering blood pressure among hypertensives in both males and females. Hypertensive patients on betablocker and/or thiazide therapy were compared in cross-section study with their age, blood pressure, fat intake, serum lipid profile, BMI, and serum albumin in males and females. Dietary fat intake and serum lipid profile were income related. Betablocker and diuretics therapy in combination with dietary fat intervention was beneficial for prolonged dyslipidemia control. Serum cholesterol level was main contributing factor dependent on BMI, duration of drug, and socio-economic factors. Fat intake contributed in hypertension and serum cholesterol levels. A cross-sectional data analysis showed beneficial effects of “low fat-salt-smoking-alcohol consumption and combined polyunsaturated fatty acid with antihypertensive therapy approach” to keep normal dyslipidemia and hypertension. Low fat intake, low salt, smoking, alcohol consumption, and combination of dietary oil supplements with lipid betablockers and diuretic modulators were associated with low hypertension and controlled dyslipidemia in Asian sedentary population.

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Acknowledgments

The work is part of graduate MSc dissertation submitted by first author to National Institute of Nutrition (Indian Council of Medical Research), Hyderabad. The graduate supervision of Drs T. C. Raghuram, MD, PhD and Kamla Krishnaswamy, MD is highly appreciated. The mentorship of cardiothoracic surgery team and clinical facility at the unit of Dr U. Brahmaji Rao, MD is highly appreciated at Osmania General Hospital. The help of physicians at CSIR, RRL, NGRI, CCMB dispensaries is highly appreciated. The discussion and interpretation of data was performed at Department of Nutrition, Food and Exercise Science, College of Human Sciences, Florida State University with Professor Robert J. Moffatt, PhD, MPH.

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Authors and Affiliations

  1. Toxicology and Drug Research Center, National Institute of Nutrition (ICMR), Hyderabad, India

    Rakesh Sharma, T. C. Raghuram & Kamla Krishnaswamy

  2. Cardiothoracic Surgery Department, Osmania General Hospital, Hyderabad, India

    U. Brahmoji Rao

  3. Department of Nutrition, Food and Exercise Science, Florida State University, Tallahassee, FL, 32304, USA

    Robert J. Moffatt

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  1. Rakesh Sharma
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  2. T. C. Raghuram
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  3. U. Brahmoji Rao
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  5. Kamla Krishnaswamy
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Correspondence to Rakesh Sharma.

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Sharma, R., Raghuram, T.C., Rao, U.B. et al. The effect of fat intake and antihypertensive drug therapy on serum lipid profile: a cross-sectional survey of serum lipids in male and female hypertensives. Mol Cell Biochem 343, 37–47 (2010). https://doi.org/10.1007/s11010-010-0496-4

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