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Antiatherogenic and radioprotective role of folic acid in whole body γ-irradiated mice

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Abstract

Free radical mediated oxidative damage is one of the prime factors for atherogenic changes in humans. We have shown that the folic acid administration reduced the risk of the atherogenic factors induced by γ -radiation. Folic acid administration prevented the radiation induced increase in the plasma lipoprotein lipase activity and also prevented the radiation-induced increase in the hepatic cholesterol and triglycerides levels. These results indicate the role of folic acid as an antiatherogenic agent. Further, we also report the radioprotective property of folic acid as demonstrated by reduction in the radiation induced membrane damage as measured by lipid peroxidation products and DNA damage, which was measured by alkaline comet assay.

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Abbreviations

FA:

Folic acid

TBARS:

2-thiobarbituric acid like reactive substances

TC:

total cholesterol

TG:

total triglycerides

HDL-C:

high density lipoprotein cholesterol

LDL-C:

very low density lipoprotein cholesterol and low density lipoprotein cholesterol

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Authors and Affiliations

  1. Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India

    Madan Sadashiv Pote, Nitin Motilal Gandhi & Kaushala Prasad Mishra

Authors
  1. Madan Sadashiv Pote
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  2. Nitin Motilal Gandhi
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  3. Kaushala Prasad Mishra
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Correspondence to Kaushala Prasad Mishra.

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Pote, M.S., Gandhi, N.M. & Mishra, K.P. Antiatherogenic and radioprotective role of folic acid in whole body γ-irradiated mice. Mol Cell Biochem 292, 19–25 (2006). https://doi.org/10.1007/s11010-006-9135-5

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  • DOI: https://doi.org/10.1007/s11010-006-9135-5

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