Abstract
Objectives
Severe Maternal Morbidity (SMM) is a group of pregnancy complications in which a woman nearly dies. Despite its increasing prevalence, little research has evaluated geographic patterns of SMM and the underlying social determinants that influence excess risk. This study examined the spatial clustering of SMM across South Carolina, US, and its associations with place-based social and environmental factors.
Methods
Hospitalized deliveries from 2012 to 2017 were analyzed using Kulldorff's spatial scan statistic to locate areas with abnormally high rates of SMM. SMM patients inside and outside risk clusters were compared using Generalized Estimating Equations (GEE) to determine underlying individual and community-level risk factors.
Results
GEE models revealed that the odds of living in a high-risk SMM21 (SMM including blood transfusions) cluster was 2.49 times higher among Black patients (p < .001) compared to those outside of a high-risk cluster. Women residing in a high-risk SMM20 (SMM excluding blood transfusions) cluster were 1.38 times more likely to experience the most number of extremely hot days and 1.70 times more likely to present with obesity than women in a low-risk SMM cluster (p < .001).
Conclusions
This study is the first to characterize the geographic clustering of SMM risk in the US. Our geospatial approach contributes a novel understanding to factors which influence SMM beyond patient-level characteristics and identifies the impact of hot ambient temperature on maternal morbidity. Findings address an important literature gap surrounding place-based risk factors by explaining the contextual social and built environmental factors that drive SMM risk.
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Data Availability
Data used in this manuscript were de-identified hospitalized delivery discharges authorized by the South Carolina Department of Health and Environmental Control and allowed for publication.
References
Admon, L. K., Winkelman, T. N. A., Zivin, K., Terplan, M., Mhyre, J. M., & Dalton, V. K. (2018). Racial and ethnic disparities in the incidence of severe maternal morbidity in the United States 2012–2015. Obstetrics and Gynecology, 132(5), 1158–1166. https://doi.org/10.1097/AOG.0000000000002937
American Medical Association. (2020). Trends in health care spending. Retrieved from: www.ama-assn.org/about/research/trends-health-care-spending.
Assibey-Mensah, V., Glantz, J. C., Hopke, P. K., Jusko, T. A., Thevenet-Morrison, K., Chalupa, D., & Rich, D. Q. (2019). Ambient wintertime particulate air pollution and hypertensive disorders of pregnancy in Monroe county New York. Environmental Research, 168(1), 25–31. https://doi.org/10.1016/j.envres.2018.09.003
Aziz, A., Gyamfi-Bannerman, C., Siddiq, Z., Wright, J. D., Goffman, D., Sheen, J. J., D’Alton, M. E., & Friedman, A. M. (2019). Maternal outcomes by race during postpartum readmissions. American Journal of Obstetrics and Gynecology, 220(5), 484.e1-484.e10. https://doi.org/10.1016/j.ajog.2019.02.016
Ballinger, G. A. (2004). Using generalized estimating equations for longitudinal data analysis. Organizational Research Methods, 7(2), 127–150. https://doi.org/10.1177/1094428104263672
Basu, R., Malig, B., & Ostro, B. (2010). High ambient temperature and the risk of preterm delivery. American Journal of Epidemiology, 172(10), 1108–1117. https://doi.org/10.1093/aje/kwq170
Booker, W. A., Gyamfi-Bannerman, C., Sheen, J. J., Wright, J. D., Siddiq, Z., D’Alton, M. E., & Friedman, A. M. (2018). Maternal outcomes by race for women aged 40 years or older. Obstetrics and Gynecology, 132(2), 404–413. https://doi.org/10.1097/AOG.0000000000002751
Brown, H. L., Small, M., Taylor, Y. J., Chireau, M., Howard, D. L. (2011). Near miss maternal mortality in a multiethnic population. Annals of Epidemiology, 21(2): 73–77.
Callaghan, W. M., Creanga, A. A., & Kuklina, E. V. (2012). Severe maternal morbidity among delivery and postpartum hospitalizations in the United States. Obstetrics and Gynecology, 120(5), 1029–1036. https://doi.org/10.1097/aog.0b013e31826d60c5
Centers for Disease Control and Prevention. (2020). Severe maternal morbidity in the United States. Retrieved from: www.cdc.gov/reproductivehealth/maternalinfanthealth/severematernalmorbidity.html.
Chambers, B. D., Baer, R. J., McLemore, M. R., & Jelliffe-Pawlowski, L. L. (2019). Using index of concentration at the extremes as indicators of structural racism to evaluate the association with preterm birth and infant mortality-California 2011–2012. Journal of Urban Health, 96(2), 159–170. https://doi.org/10.1007/s11524-018-0272-4
Chong, S., Nelson, M., Byun, R., Harris, L., Eastwood, J., & Jalaludin, B. (2013). Geospatial analyses to identify clusters of adverse antenatal factors for targeted interventions. Int J Health Geography, 12, 46. https://doi.org/10.1186/1476-072X-12-46
Cil, G., & Cameron, T. A. (2017). Potential climate change health risks from increases in heat waves: Abnormal birth outcomes and adverse maternal health conditions. Risk Analysis: An International Journal, 37(11), 2066–2079. https://doi.org/10.1111/risa.12767
Creanga, A. A., Bateman, B. T., Kuklina, E. V., & Callaghan, W. M. (2014a). Racial and ethnic disparities in severe maternal morbidity: A multistate analysis, 2008-2010. American Journal of Obstetrics and Gynecology, 210(5), 435.e1–435.e8.
Creanga, A. A., Berg, C. J., Ko, J. Y., Farr, S. L., Tong, V. T., Bruce, F. C., & Callaghan, W. M. (2014b). Maternal mortality and morbidity in the United States: Where are we now? Journal of Women’s Health, 23(1), 3–9. https://doi.org/10.1089/jwh.2013.4617
ESRI 2018. ArcGIS Pro: Release 2.3.3. Redlands, CA: Environmental Systems Research Institute.
Fingar, K. R., Hambrick, M. M., Heslin, K. C., and Moore, J. E. (2018). Trends and disparities in delivery hospitalizations involving severe maternal morbidity 2006–2015: Statistical brief #243. Rockville (MD): Healthcare Cost and Utilization Project.
Geller, S. E., Koch, A. R., Garland, C. E., MacDonald, E. J., Storey, F., & Lawton, B. (2018). A global view of severe maternal morbidity: Moving beyond maternal mortality. Reproductive Health, 15(Suppl 1), 98. https://doi.org/10.1186/s12978-018-0527-2
Grobman, W. A., Bailit, J. L., Rice, M. M., Wapner, R. J., Reddy, U. M., Varner, M. W., Thorp, J. M. J., Leveno, K. J., Caritis, S. N., Iams, J. D., Tita, A. T., Saade, G., Sorokin, Y., Rouse, D. J., Blackwell, S. C., Tolosa, J. E., & Van Dorsten, J. P. (2014). Frequency of and factors associated with severe maternal morbidity. Obstetrics and Gynecology, 123(4), 804–810. https://doi.org/10.1097/AOG.0000000000000173
Guglielminotti, J., Landau, R., Friedman, A., & Guohua, L. (2018a). Pulmonary hypertension during pregnancy in New York state 2003–2014. Maternal and Child Health Journal, 23(2), 277–284. https://doi.org/10.1007/s10995-018-2652-5
Guglielminotti, J., Landau, R., Wong, C. A., & Li, G. (2018b). Patient-, hospital-, and neighborhood-level factors associated with severe maternal morbidity during childbirth: A cross-sectional study in New York state, 2013–2014. Maternal and Child Health Journal, 23(1), 82–91. https://doi.org/10.1007/s10995-018-2596-9
Hansen A., & Moloney, M. (2019). Pregnancy-related mortality and severe maternal morbidity in rural Appalachia: Established risks and the need to know more. The Journal Of Rural Health, 36(1), 3–8.
Hirshberg, A., & Srinivas, S. K. (2017). Epidemiology of maternal morbidity and mortality. Seminars in Perinatology, 41(6), 332–337.
Hitti, J., Sienas, L., Walker, S., Benedetti, T. J., & Easterling, T. (2018). Contribution of hypertension to severe maternal morbidity. American Journal of Obstetrics and Gynecology, 219(4), 405.e1–405.e7.
Højsgaard, S., Halekoh, U., & Yan, J. (2006). The R package geepack for generalized estimating equations. Journal of Statistical Software, 15(2), 1–11.
Howell, E. A., Egorova, N. N., Balbierz, A., Zeitlin, J., & Hebert, P. L. (2016). Site of delivery contribution to black-white severe maternal morbidity disparity. American Journal of Obstetrics and Gynecology, 215(2), 143–152. https://doi.org/10.1016/j.ajog.2016.05.007
Huang, L., Stinchcomb, D. G., Pickle, L. W., Dill, J., & Berrigan, D. (2009). Identifying clusters of active transportation using spatial scan statistics. American Journal of Preventive Medicine, 37(2), 157–166. https://doi.org/10.1016/j.amepre.2009.04.021
Klima, C., Norr, K., Vonderheid, S., & Handler, A. (2009). Introduction of CenteringPregnancy in a public health clinic. Journal of Midwifery & Women’s Health, 54(1), 27–34.
Krieger, N., Kim, R., Feldman, J., & Waterman, P. D. (2018). Using the Index of Concentration at the Extremes at multiple geographical levels to monitor health inequities in an era of growing spatial social polarization: Massachusetts, USA (2010–14). International Journal of Epidemiology, 47(3), 788–819.
Krieger, N., Singh, N., & Waterman, P. D. (2016). Metrics for monitoring cancer inequities: Residential segregation, the index of concentration at the extremes (ICE), and breast cancer estrogen receptor status (USA, 1992–2012). Cancer Causes and Control, 27, 1139–1151. https://doi.org/10.1007/s10552-016-0793-7
Kulldorff, M., Feuer, E. J., Miller, B. A., & Freedman, L. S. (1997). Breast cancer clusters in the northeast United States: A geographic analysis. American Journal of Epidemiology, 146, 161–170. https://doi.org/10.1093/oxfordjournals.aje.a009247
Laditka, S. B., Laditka, J. N., & Probst, J. C. (2006). Racial and ethnic disparities in potentially avoidable delivery complications among pregnant Medicaid beneficiaries in South Carolina. Maternal and Child Health Journal, 10, 339–350. https://doi.org/10.1007/s10995-006-0071-5
Langenberg, C., Hardy, R., Kuh, D., Brunner, E., & Wadsworth, M. (2003). Central and total obesity in middle aged men and women in relation to lifetime socioeconomic status: Evidence from a national birth cohort. Journal of Epidemiology & Community Health, 57, 816–822. https://doi.org/10.1136/jech.57.10.816
Leonard, S. A., Main, E. K., & Carmichael, S. L. (2019). The contribution of maternal characteristics and cesarean delivery to an increasing trend of severe maternal morbidity. BMC Pregnancy and Childbirth, 19, 16. https://doi.org/10.1186/s12884-018-2169-3
Liang, K., & Zeger, S. L. (1986). Longitudinal data analysis using generalized linear models. Biometrika, 73, 13–22. https://doi.org/10.1093/biomet/73.1.13
Liese, K. L., Mogos, M., Abboud, S., Decocker, K., Koch, A. R., & Geller, S. E. (2019). Racial and ethnic disparities in severe maternal morbidity in the United States. Journal of Racial and Ethnic Health Disparities, 6(4), 790. https://doi.org/10.1007/s40615-019-00577-w
Lisonkova, S., Haslam, M. D., Dahlgren, L., Chen, I., Synnes, A. R., & Lim, K. I. (2016). Maternal morbidity and perinatal outcomes among women in rural versus urban areas. CMAJ, 188(17–18), E456–E465. https://doi.org/10.1503/cmaj.151382
Lisonkova, S., Muraca, G. M., Potts, J., Liauw, J., Chan, W. S., Skoll, A., & Lim, K. I. (2017). Association between prepregnancy body mass index and severe maternal morbidity. JAMA, 318(18), 1777–1786. https://doi.org/10.1001/jama.2017.16191
Massey, D. S. (1996). The age of extremes: Concentrated affluence and poverty in the twenty-first century. Demography, 33, 395–412. https://doi.org/10.2307/2061773
Metcalfe, A., Wick, J., & Ronksley, P. (2018). Racial disparities in comorbidity and severe maternal morbidity/mortality in the United States: An analysis of temporal trends. Acta Obstetricia et Gynecologica Scandinavica, 97(1), 89–96.
Nagahawatte, N. T., & Goldenberg, R. L. (2008). Poverty, maternal health, and adverse pregnancy outcomes. Annals of the New York Academy of Sciences, 1136, 80–85. https://doi.org/10.1196/annals.1425.016
Oliveira, F. C., Surita, F. G., Pinto e Silva, J. L., Cecatti, J. G., Parpinelli, M. A., Haddad, S. M., Costa M. L., Pacagnella R. C., Sousa M. H., & Souza J. P. (2014). Severe maternal morbidity and maternal near miss in the extremes of reproductive age: Results from a national cross- sectional multicenter study. BMC Pregnancy and Childbirth, 14, 77.
Owens, D. C., & Fett, S. M. (2019). Black maternal and infant health: historical legacies of slavery. American Journal of Public Health, 109, 1342–1345. https://doi.org/10.2105/AJPH.2019.305243
Oyana, T. J., Matthews-Juarez, P., Cormier, S. A., Xu, X., & Juarez, P. D. (2015). Using an external exposome framework to examine pregnancy-related morbidities and mortalities: Implications for health disparities research. International Journal of Environmental Research and Public Health. https://doi.org/10.3390/ijerph13010013
Pallasmaa, N., Ekblad, U., Gissler, M., & Alanen, A. (2014). The impact of maternal obesity, age, pre-eclampsia and insulin dependent diabetes on severe maternal morbidity by mode of delivery—a register-based cohort study. Archives of Gynecology and Obstetrics, 291, 311–318.
Prisma Health. (n.d.). CenteringPregnancy. Retrieved from: https://www.ghs.org/healthcareservices/primary-care/ob-gyn/ob-gyn-center/centering/.
R Core Team (2021). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL https://www.R-project.org/.
Root, E. D., Meyer, R. E., & Emch, M. E. (2009). Evidence of localized clustering of gastroschisis births in North Carolina, 1999–2004. Social Science & Medicine, 68, 1361–1367. https://doi.org/10.1016/j.socscimed.2009.01.034
Shamshirsaz, A. A., & Dildy, G. A. (2018). Reducing maternal mortality and severe maternal morbidity: The role of critical care. Clinical Obstetrics and Gynecology, 61(2), 359–371.
Vose, R. S., Applequist, S., Squires, M., Durre, I., Menne, M. J., Williams, C. N., Jr., Fenimore, C., Gleason, K., & Arndt, D. (2014). Improved historical temperature and precipitation time series for US climate divisions. Journal of Applied Meteorology and Climatology, 53(5), 1232–1251. https://doi.org/10.1175/JAMC-D-13-0248.1
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This project was developed with support from Appalachian State University’s University Research Council (URC).
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SH-conception or design of the work, data analysis and interpretation, drafting the article; JR-conception or design of the work, securing data, data analysis and interpretation, drafting the article; and MS -conception or design of the work, securing data, data analysis and interpretation, drafting the article.
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The research protocol was reviewed and approved by university IRB and deemed exempt (Study #19–0186) based on the exemption category “secondary data”.
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Harden, S.R., Runkle, J.D. & Sugg, M.M. An Exploratory Spatiotemporal Analysis of Socio-Environmental Patterns in Severe Maternal Morbidity. Matern Child Health J 26, 1077–1086 (2022). https://doi.org/10.1007/s10995-021-03330-0
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DOI: https://doi.org/10.1007/s10995-021-03330-0