Abstract
Objectives
Social and contextual factors underlying the continually disproportionate and burdensome risk of adverse health outcomes experienced by Black women in the US are underexplored in the literature. The aim of this study was to use an index based on area-level population distributions of race and income to predict risk of death during pregnancy and up to 1 year postpartum among women in Louisiana.
Methods
Using vital records data provided by the Louisiana Department of Health 2016–2017 (n = 125,537), a modified Poisson model was fit with generalized estimating equations to examine the risk of pregnancy-associated death associated with census tract-level values of the Index of Concentration at the Extremes (ICE)—grouped by tertile—while adjusting for both individual and tract-level confounders.
Results
Analyses resulted in an estimated 1.73 (95% CI 1.02–2.93) times increased risk for pregnancy-associated death for those in areas which were characterized by concentrated deprivation (high proportions of Black and low-income residents) relative to those in areas of concentrated privilege (high proportions of white and high-income residents), independent of other factors.
Conclusions for Practice
In addition to continuing to consider the deeply entrenched racism and economic inequality that shape the experience of pregnancy-associated death, we must also consider their synergistic effect on access to resources, maternal population health, and health inequities.
Similar content being viewed by others
Data Availability
Not applicable.
Code Availability
Not applicable.
References
Attanasio, L. B., & Hardeman, R. R. (2019). Declined care and discrimination during the childbirth hospitalization. Social Science & Medicine, 232, 270–277. https://doi.org/10.1016/j.socscimed.2019.05.008
Bailey, Z. D., Krieger, N., Agenor, M., Graves, J., Linos, N., & Bassett, M. T. (2017). Structural racism and health inequities in the USA: Evidence and interventions. Lancet, 389(10077), 1453–1463. https://doi.org/10.1016/S0140-6736(17)30569-X
Burgess, A. P. H., Dongarwar, D., Spigel, Z., Salihu, H. M., Moaddab, A., Clark, S. L., & Fox, K. (2020). Pregnancy-related mortality in the United States, 2003–2016: Age, race, and place of death. American Journal of Obstetrics and Gynecology, 222(5), 489 e481–489 e488. https://doi.org/10.1016/j.ajog.2020.02.020
Board of Governors of the Federal Reserve System. (2017). Fair Lending Regulations and Statutes: Fair Housing Act. Retrieved from https://www.federalreserve.gov/boarddocs/supmanual/cch/fair_lend_fhact.pdf
Carey, G., & Crammond, B. (2015). Systems change for the social determinants of health. BMC Public Health, 15, 662. https://doi.org/10.1186/s12889-015-1979-8
Chambers, B. D., Baer, R. J., McLemore, M. R., & Jelliffe-Pawlowski, L. L. (2019). Using Index of Concentration at the Extremes as indicators of structural racism to evaluate the association with preterm birth and infant mortality—California, 2011–2012. Journal of Urban Health, 96(2), 159–170. https://doi.org/10.1007/s11524-018-0272-4
Creanga, A. A., Berg, C. J., Ko, J. Y., Farr, S. L., Tong, V. T., Bruce, F. C., & Callaghan, W. M. (2014). Maternal mortality and morbidity in the United States: Where are we now? Journal of Women’s Health (Larchmt), 23(1), 3–9. https://doi.org/10.1089/jwh.2013.4617
Creanga, A. A., Syverson, C., Seed, K., & Callaghan, W. M. (2017). Pregnancy-related mortality in the United States, 2011–2013. Obstetrics & Gynecology, 130(2), 366–373. https://doi.org/10.1097/AOG.0000000000002114
DiGiuseppe, D. L., Aron, D. C., Ranbom, L., Harper, D. L., & Rosenthal, G. E. (2002). Reliability of birth certificate data: A multi-hospital comparison to medical records information. Maternal and Child Health Journal, 6, 169–179.
Gee, G. C., & Payne-Sturges, D. C. (2004). Environmental health disparities: A framework integrating psychosocial and environmental concepts. Environmental Health Perspectives, 112(17), 1645–1653. https://doi.org/10.1289/ehp.7074
Geronimus, A. T. (1992). The weathering hypothesis and the health of African-American women and infants: Evidence and speculations. Ethnicity & Disease, 2(3), 207–221.
Giang, T., Karpyn, A., Laurison, H. B., Hillier, A., & Perry, R. D. (2008). Closing the grocery gap in underserved communities: The creation of the Pennsylvania Fresh Food Financing Initiative. Journal of Public Health Management and Practice, 14(3), 272–279. https://doi.org/10.1097/01.PHH.0000316486.57512.bf
Groos, M., Wallace, M. E., Hardeman, R. R., & Theall, K. P. (2018). Measuring inequity: A systematic review of methods used to quantify structural racism. Journal of Health Disparities Research and Practice, 11(2), 13.
Hoffman, K. M., Trawalter, S., Axt, J. R., & Oliver, M. N. (2016). Racial bias in pain assessment and treatment recommendations, and false beliefs about biological differences between blacks and whites. Proceedings of the National Academy of Sciences USA, 113(16), 4296–4301. https://doi.org/10.1073/pnas.1516047113
Hohl, B. C., Kondo, M. C., Kajeepeta, S., MacDonald, J. M., Theall, K. P., Zimmerman, M. A., & Branas, C. C. (2019). Creating safe and healthy neighborhoods with place-based violence interventions. Health Affairs (Millwood), 38(10), 1687–1694. https://doi.org/10.1377/hlthaff.2019.00707
Huynh, M., Parker, J. D., Harper, S., Pamuk, E., & Schoendorf, K. C. (2005). Contextual effect of income inequality on birth outcomes. International Journal of Epidemiology, 34(4), 888–895. https://doi.org/10.1093/ije/dyi092
Hystad, P., Davies, H. W., Frank, L., Van Loon, J., Gehring, U., Tamburic, L., & Brauer, M. (2014). Residential greenness and birth outcomes: Evaluating the influence of spatially correlated built-environment factors. Environmental Health Perspectives, 122(10), 1095–1102. https://doi.org/10.1289/ehp.1308049
Jee-Lyn Garcia, J., & Sharif, M. Z. (2015). Black lives matter: A commentary on racism and public health. American Journal of Public Health, 105(8), e27–e30. https://doi.org/10.2105/AJPH.2015.302706
Jones, C. P. (2001). Invited commentary: “Race”, racism, and the practice of epidemiology. American Journal of Epidemiology, 154(4), 299–304. https://doi.org/10.1093/aje/154.4.299 (discussion 305–296).
Kandasamy, V., Hirai, A. H., Kaufman, J. S., James, A. R., & Kotelchuck, M. (2020). Regional variation in Black infant mortality: The contribution of contextual factors. PLoS One, 15(8), e0237314. https://doi.org/10.1371/journal.pone.0237314
Kawachi, I., & Kennedy, B. P. (1997). Health and social cohesion: Why care about income inequality? BMJ, 314(7086), 1037–1040. https://doi.org/10.1136/bmj.314.7086.1037
Kieltyka, L., Mehta, P. Schoellmann, K., Lake, C. (2018). Louisiana Maternal Mortality Review Report 2011–2016.
Krieger, N. (2012). Methods for the scientific study of discrimination and health: An ecosocial approach. American Journal of Public Health, 102(5), 936–944. https://doi.org/10.2105/AJPH.2011.300544
Krieger, N., Waterman, P. D., Gryparis, A., & Coull, B. A. (2015). Black carbon exposure, socioeconomic and racial/ethnic spatial polarization, and the Index of Concentration at the Extremes (ICE). Health & Place, 34, 215–228. https://doi.org/10.1016/j.healthplace.2015.05.008
Krieger, N., Singh, N., & Waterman, P. D. (2016a). Metrics for monitoring cancer inequities: Residential segregation, the Index of Concentration at the Extremes (ICE), and breast cancer estrogen receptor status (USA, 1992–2012). Cancer Causes & Control, 27(9), 1139–1151. https://doi.org/10.1007/s10552-016-0793-7
Krieger, N., Waterman, P. D., Spasojevic, J., Li, W., Maduro, G., & Van Wye, G. (2016b). Public health monitoring of privilege and deprivation with the Index of Concentration at the Extremes. American Journal of Public Health, 106(2), 256–263. https://doi.org/10.2105/AJPH.2015.302955
Lee, J. P., Ponicki, W., Mair, C., Gruenwald, P., & Ghanem, L. (2020). What explains the concentration of off-premise alcohol outlets in Black neighborhoods? SSM-Population Health, 12, 100669.
Li, M., Johnson, S. B., Newman, S., & Wiley, A. W. (2019). Residential mobility and long-term exposure to neighborhood poverty among children born in poor families: A U.S. longitudinal cohort study. Social Science & Medicine, 226, 69–76.
Link, B. G., & Phelan, J. (1995). Social conditions as fundamental causes of disease. Journal of Health and Social Behavior, 35(Spec No 80–94), 80.
McClure, E., Feinstein, L., Cordoba, E., Douglas, C., Emch, M., Robinson, W., Galea, S., & Aiello, A. E. (2019). The legacy of redlining in the effect of foreclosures on Detroit residents’ self-rated health. Health & Place, 55, 9–19. https://doi.org/10.1016/j.healthplace.2018.10.004
Mendez, D. D., Hogan, V. K., & Culhane, J. F. (2013). Stress during pregnancy: The role of institutional racism. Stress and Health, 29(4), 266–274. https://doi.org/10.1002/smi.2462
Morning, A. (2012). Everyone knows it’s a social construct: Contemporary science and the nature of race. Sociological Focus, 40(4), 436–454.
Rossen, L. M., Womack, L. S., Hoyert, D. L., Anderson, R. N., & Uddin, S. F. G. (2020). The impact of the pregnancy checkbox and misclassification on maternal mortality trends in the United States, 1999–2007. National Center for Health Statistics. Vital and Health Statistics, 3(44), 1–61.
Sen, M., & Wasow, O. (2016). Race as a bundle of sticks: Designs that estimate effects of seemingly immutable characteristics. Annual Review of Political Science, 19(19), 499–522. https://doi.org/10.1146/annurev-polisci-032015-010015
Shih, M., Bonam, C., Sanchez, D., & Peck, C. (2007). The social construction of race: Biracial identity and vulnerability to stereotypes. Cultural Diversity and Ethnic Minority Psychology, 13(2), 125–133. https://doi.org/10.1037/1099-9809.13.2.125
Shrimali, B. P., Pearl, M., Karasek, D., Reid, C., Abrams, B., & Mujahid, M. (2020). Neighborhood privilege, preterm delivery, and related racial/ethnic disparities: An intergenerational application of the Index of Concentration at the Extremes. American Journal of Epidemiology, 189(5), 412–421. https://doi.org/10.1093/aje/kwz279
Shumate, C., Hoyt, A., Liu, C., Kleinert, A., & Canfield, M. (2019). Understanding how the concentration of neighborhood advantage and disadvantage affects spina bifida risk among births to non-Hispanic white and Hispanic women, Texas, 1999–2014. Birth Defects Research, 111(14), 982–990. https://doi.org/10.1002/bdr2.1374
Smith, G. D. (1996). Income inequality and mortality: Why are they related? BMJ, 312(7037), 987–988.
Story, M., Kaphingst, K. M., Robinson-O’Brien, R., & Glanz, K. (2008). Creating healthy food and eating environments: Policy and environmental approaches. Annual Review of Public Health, 29, 253–272. https://doi.org/10.1146/annurev.publhealth.29.020907.090926
Wallace, M. E., Crear-Perry, J., Green, C., Felker-Kantor, E., & Theall, K. (2019). Privilege and deprivation in Detroit: Infant mortality and the Index of Concentration at the Extremes. International Journal of Epidemiology, 48(1), 207–216. https://doi.org/10.1093/ije/dyy149
Wang, E., Glazer, K. B., Howell, E. A., & Janevic, T. M. (2020). Social determinants of pregnancy-related mortality and morbidity in the United States: A systematic review. Obstetrics & Gynecology, 135(4), 896–915. https://doi.org/10.1097/AOG.0000000000003762
Ward, J. B., Gartner, D. R., Keyes, K. M., Fliss, M. D., McClure, E. S., & Robinson, W. R. (2019). How do we assess a racial disparity in health? Distribution, interaction, and interpretation in epidemiological studies. Annals of Epidemiology, 29, 1–7. https://doi.org/10.1016/j.annepidem.2018.09.007
Wilkinson, R. G. (1997). Socioeconomic determinants of health. Health inequalities: Relative or absolute material standards? BMJ, 314(7080), 591–595. https://doi.org/10.1136/bmj.314.7080.591
Williams, D. R., & Collins, C. (2001). Racial residential segregation: A fundamental cause of racial disparities in health. Public Health Reports, 116(5), 404–416. https://doi.org/10.1093/phr/116.5.404
Funding
This work was supported by the National Institute of Child Health and Human Development Grant Numbers R01HD092653 and R01HD096070. The funding source had no involvement in the conduct of the research or preparation of the article. Its contents are solely the responsibility of the authors and do not necessarily represent the official position of the National Institutes of Health or the Louisiana Department of Health.
Author information
Authors and Affiliations
Contributions
LD conceived the study. LD and MW conducted and interpreted the analysis. BC, JP, and KT interpreted the analysis and were major contributors in writing the manuscript. All authors read, contributed to, and agreed to the final version of the manuscript prior to submission. The authors would also like to acknowledge Dr. Kate Babineau for her assistance with data visualization for Fig. 1.
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical Approval
As all data were deidentified, this study was deemed exempt the Tulane University Institutional Review Board.
Consent to Participate
Not applicable.
Consent for Publication
Not applicable.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Dyer, L., Chambers, B.D., Crear-Perry, J. et al. The Index of Concentration at the Extremes (ICE) and Pregnancy-Associated Mortality in Louisiana, 2016–2017. Matern Child Health J 26, 814–822 (2022). https://doi.org/10.1007/s10995-021-03189-1
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10995-021-03189-1