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Thermal behavior and thermo-mechanical properties of biocompatible poly(lactic acid)/allyl-POSS nanohybrids

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Abstract

Polysilsesquioxanes are extensively studied as durable and anti-adherent coatings for medical devices due to their superhydrophobic properties. However, their particular influence on the thermo-mechanical properties and biocompatibility of poly(lactic acid) (PLA)-based materials obtained by melt compounding is scarce. Herein, a facile and promising method to improve the performances of PLA for biomedical applications via the incorporation of different mass proportions of POSS nanoparticles with allyl-heptaisobutyl (AH-POSS) substituent through a melt-blending technique is proposed. The thermal, morpho-structural, mechanical properties at room (RT) and body temperatures (BT), and in vitro biocompatibility of the developed PLA/AH-POSS nanohybrids were investigated. AH-POSS nanoparticles were found to have simultaneous nucleation and plasticizing effects on the PLA nanohybrids, inducing enhanced thermal resistance and easy control of crystallinity while preserving PLA’s biocompatibility. An interesting effect of AH-POSS on the mechanical properties of PLA at body temperature was observed. These results indicate the considerable potential of the PLA/AH-POSS nanohybrids obtained by melt compounding in the fabrication of biomedical devices.

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Acknowledgements

This work was supported by a grant of the Ministry of Research, Innovation and Digitization, CNCS/CCCDI – UEFISCDI, project number 67TE/2020, within PNCDI III

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Authors and Affiliations

  1. National Institute for Research & Development in Chemistry and Petrochemistry - ICECHIM, 202 Splaiul Independentei, 060021, Bucharest, Romania

    Adriana Nicoleta Frone, Marius Stelian Popa, Cristian Andi Nicolae, Augusta Raluca Gabor, Monica Florentina Raduly, Radu Claudiu Fierascu & Denis Mihaela Panaitescu

  2. Cantacuzino National Medical-Military Institute for Research and Development, 103 Spl. Independentei, 050096, Bucharest, Romania

    Dora Dominica Baciu

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  1. Adriana Nicoleta Frone
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  2. Dora Dominica Baciu
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  3. Marius Stelian Popa
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  4. Cristian Andi Nicolae
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  5. Augusta Raluca Gabor
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  6. Monica Florentina Raduly
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  7. Radu Claudiu Fierascu
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  8. Denis Mihaela Panaitescu
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Contributions

ANF contributed to conceptualization, methodology, funding acquisition, and writing—review and editing; DDB contributed to formal analysis and investigation; MSP contributed to methodology and investigation; CAN contributed to investigation and data curation; ARG, MFR and RCF contributed to investigation; DMP contributed to writing—review and editing and validation.

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Correspondence to Adriana Nicoleta Frone.

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Frone, A.N., Baciu, D.D., Popa, M.S. et al. Thermal behavior and thermo-mechanical properties of biocompatible poly(lactic acid)/allyl-POSS nanohybrids. J Therm Anal Calorim 148, 10465–10479 (2023). https://doi.org/10.1007/s10973-023-12196-z

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