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Micellar thermodynamics of voriconazole cyclodextrin-HS15 complex in glucose and NaCl solution

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Abstract

The hydrodynamic radius and size dispersion of cyclodextrin-micelle complexes loaded with voriconazole in glucose and NaCl solutions were studied in detail by dynamic light scattering technique. The critical micelle concentration (CMC) was determined by surface tension, and the relevant air–water interface parameters and micellization thermodynamic parameters were calculated. In the environment of glucose and NaCl, the CMC value decreases with the increase in the concentration of the additive. Glucose forms more stable hydrophilic ends by binding to the micelle hydrophilic group. NaCl acts as a water structure building ion to provide hydrophobic force to the gum surfactant molecules and promote the formation of micelles. The results of insoluble particles are consistent with the CMC results, which further supports the results obtained.

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Acknowledgements

This work has been supported by the Southwest University Dr. Fund projects [SWU110056, SWU110057] and Chongqing Engineering Research Center for Pharmaceutical Process and Quality Control Capacity building project [CSTC2012gg-yyjsb10002-33].

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Authors and Affiliations

  1. College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China

    Yiqi Li, Hui Wu, Yuhan Li, Hongchun Pan & Hong Liu

  2. Chongqing Engineering Research Center for Pharmaceutical Process and Quality Control, Chongqing, 400715, China

    Yiqi Li, Hui Wu, Yuhan Li, Hongchun Pan & Hong Liu

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  1. Yiqi Li
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Correspondence to Hongchun Pan or Hong Liu.

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Li, Y., Wu, H., Li, Y. et al. Micellar thermodynamics of voriconazole cyclodextrin-HS15 complex in glucose and NaCl solution. J Therm Anal Calorim 145, 59–66 (2021). https://doi.org/10.1007/s10973-020-09692-x

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