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Spectral, thermal and biological characterization of complexes with a Schiff base bearing triazole moiety as potential antimicrobial species

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Abstract

A novel series of complexes ML(ClO4)·nH2O (M: Co, Ni, Cu, Zn; HL: 2-[(E)-(1H-1,2,4-triazol-3-ylimino)methyl]phenol) have been synthesized and characterized as mononuclear species. The features of complexes have been assigned from microanalytical, FAB-MS, IR, UV–Vis-NIR, EPR and magnetic data. The IR spectra indicate the chelate behaviour of Schiff base and the perchlorate presence either as free ion or as ligand. Electronic and magnetic data are consistent with hexa-coordination of Co(II) and Ni(II) and penta-coordination for Cu(II) ions in complexes. The simultaneous TG-DSC/MS measurements evidenced processes as water (hydration or coordination) elimination, perchlorate decomposition as well as Schiff base both fragmentation and oxidative degradation. The in vitro screening of the antimicrobial behaviour on Gram-positive and Gram-negative bacteria, as well as on fungal strains, indicates a good activity for Cu(II) and Zn(II) complexes against both planktonic or adherent cells. Moreover, Cu(II) complex also exhibited a promising antiproliferative activity on HT 29 cell line.

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Acknowledgements

The authors thank researcher Gabriela Ionită from “Ilie Murgulescu” Physical Chemistry Institute of Romanian Academy for EPR measurements.

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Authors and Affiliations

  1. Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., 050663, Bucharest, Romania

    Larisa Calu & Mihaela Badea

  2. Cellular Dynamics and Flow Cytometry Department, National Institute R&D for Biological Sciences, 296 Splaiul Independenței, 060031, Bucharest, Romania

    Larisa Calu & Rodica Olar

  3. Department of Inorganic Chemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, 1000, Ljubljana, Slovenia

    Nataša Čelan Korošin

  4. Department of Microbiology, Faculty of Biology, University of Bucharest, 1-3 Aleea Portocalilor St., 60101, Bucharest, Romania

    Mariana Carmen Chifiriuc

  5. Research Institute of the University of Bucharest, ICUB, Splaiul Independenței 91-95, Bucharest, Romania

    Mariana Carmen Chifiriuc

  6. Stefan S. Nicolau Institute of Virology, 285 Mihai Bravu Ave., Bucharest, Romania

    Coralia Bleotu

  7. “Ilie Murgulescu” Physical Chemistry Institute, Romanian Academy, 202 Splaiul Independenței, 77208, Bucharest, Romania

    Nicolae Stanică

  8. 3S-Pharmacological Consultation & Research GmbH, 1 Koenigsbergerstrasse, 27243, Harpstedt, Germany

    Luigi Silvestro & Martin Maurer

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  1. Larisa Calu
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  2. Mihaela Badea
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Correspondence to Rodica Olar.

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Calu, L., Badea, M., Čelan Korošin, N. et al. Spectral, thermal and biological characterization of complexes with a Schiff base bearing triazole moiety as potential antimicrobial species. J Therm Anal Calorim 134, 1839–1850 (2018). https://doi.org/10.1007/s10973-018-7871-x

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  • DOI: https://doi.org/10.1007/s10973-018-7871-x

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