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Thermal behavior and kinetic study of degradation for adamantan-2-one versus memantine hydrochloride

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Abstract

Adamantan-2-one is an adamantane derivative used as a precursor for different adamantane-based pharmacologically active compounds. Adamantan-2-one and memantine hydrochloride were investigated in other of our previous published papers, as pure compounds and in binary mixtures with various excipients. The aim of our study is to determine the thermal behavior of adamantan-2-one, as well as the kinetic parameters that characterize the degradation process of this precursor. The employed analytical techniques were thermal analysis (TG/DTG/HF) and FTIR spectroscopy. The TG/DTG/HF curves were recorded in air at different heating rates: β = 5, 7, 10, 12 and 15 °C min−1, in respect of the ICTAC 2000 protocol regarding the kinetic analysis. The methods used for kinetic analysis of the thermal degradation process were isoconversional methods: Friedman and Flynn–Wall–Ozawa. Modified NPK method was used for determination of kinetic parameters.

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References

  1. Bazyleva AB, Blokhin AV, Kabo GJ, Kabo AG, Sevruk VM. Thermodynamic properties of 2-adamantanone in the condensed and ideal gaseous states. Thermochim Acta. 2006;451:65–72.

    Article  CAS  Google Scholar 

  2. Budiul M, Albu P, Vlase G, Turcuş V, Vlase T. Thermogravimetric and calorimetric studies performed on memantine hydrochloride to determine its thermal behavior and possible drug-excipient interactions. J Therm Anal Calorim. 2017;127(1):555–64.

    Article  CAS  Google Scholar 

  3. Sovizi MR, Hosseini SG. Studies on the thermal behavior and decomposition kinetic of drugs cetirizine and simvastatin. J Therm Anal Calorim. 2013;111:2143–8.

    Article  CAS  Google Scholar 

  4. Brown ME, Maciejewski M, Vyazovkin S, Nomen R, Sempere J, Burnham A, et al. Computational aspects of kinetic analysis: part A: the ICTAC kinetics project-data, methods and results. Thermochim Acta. 2000;355:125–43.

    Article  CAS  Google Scholar 

  5. Vyazovkin S, Burnham AK, Criado JM, Pérez-Maqueda LA, Popescu C, Sbirrazzouli N. ICTAC kinetics committee recommendations for performing kinetic computations on thermal analysis data. Thermochim Acta. 2011;520:1–19.

    Article  CAS  Google Scholar 

  6. Friedman HL. Kinetics of thermal degradation of char-foaming plastics from thermogravimetry: application to a phenolic resin. J Polymer Sci. 1965;6C:183–95.

    Google Scholar 

  7. Flynn JH, Wall LA. A quick, direct method for the determination of activation energy from thermogravimetric data. Polym Lett. 1966;4:323–8.

    Article  CAS  Google Scholar 

  8. Ozawa T. A new method of analyzing thermogravimetric data. Bull Chem Soc Jpn. 1965;38:1881–6.

    Article  CAS  Google Scholar 

  9. Serra R, Nomen R, Sempere J. The non-parametric kinetics. A new method for the kinetic study of thermoanalytical data. J Therm Anal Calorim. 1998;52:933–43.

    Article  CAS  Google Scholar 

  10. Serra R, Sempere J, Nomen R. A new method for the kinetic study of thermoanalytical data: the non-parametric kinetics method. Thermochim Acta. 1998;316:37–45.

    Article  CAS  Google Scholar 

  11. Albu P, Doca SC, Anghel A, Vlase G, Vlase T. Thermal behavior of sodium alendronate: a kinetic study under non-isothermal conditions. J Therm Anal Calorim. 2017;127(1):571–6.

    Article  CAS  Google Scholar 

  12. Ledeţi I, Murariu M, Vlase G, Vlase T, Doca N, Ledeţi A, Şuta L-M, Olariu T. Investigation of thermal-induced decomposition of iodoform. J Therm Anal Calorim. 2017;127(1):565–70.

    Article  Google Scholar 

  13. Vlase G, Bolcu C, Modra D, Budiul MM, Ledeţi I, Albu P, Vlase T. Thermal behavior of phthalic anhydride-based polyesters. J Therm Anal Calorim. 2016;126:287–92.

    Article  CAS  Google Scholar 

  14. Patrutescu C, Vlase G, Turcus V, Ardelean D, Vlase T, Albu P. TG/DTG/DTA data used for determining the kinetic parameters of the thermal degradation process of an immunosuppressive agent: mycophenolate mofetil. J Therm Anal Calorim. 2015;121(3):983–8.

    Article  CAS  Google Scholar 

  15. Ceban I, Blajovan R, Vlase G, Albu P, Koppandi O, Vlase T. Thermoanalytical measurements conducted on repaglinide to estimate the kinetic triplet followed by compatibility studies between the antidiabetic agent and various excipients. J Therm Anal Calorim. 2016;126:195–204.

    Article  CAS  Google Scholar 

  16. Ledeţi I, Vlase G, Vlase T, Fuliaş A. Kinetic analysis of solid-state degradation of pure pravastatin versus pharmaceutical formulation. J Therm Anal Calorim. 2015;121:1103–11.

    Article  Google Scholar 

  17. Ledeti I, Vlase G, Vlase T, Bercean V, Fulias A. Kinetic of solid state degradation of transitional coordinative compounds containing functionalized 1,2,4-triazolic ligand. J Therm Anal Calorim. 2015;121(3):1049–57.

    Article  CAS  Google Scholar 

  18. Fuliaş A, Ledeţi I, Vlase G, Vlase T, Şoica C, Dehelean C, Oprean C, Bojin F, Şuta LM, Bercean V, Avram Ş. Thermal degradation, kinetic analysis, and apoptosis induction in human melanoma for oleanolic and ursolic acids. J Therm Anal Calorim. 2016;125:759–68.

    Article  Google Scholar 

  19. Wall ME. Singular value decomposition and principal component analysis. In: Berrar DP, Dubitzky W, Granzow M, editors. A practical approach to microarray data analysis, vol. 9. Norwel: Kluwer-Norwel; 2003. p. 91–109.

    Chapter  Google Scholar 

  20. Šesták J, Berggren G. Study of the kinetics of the mechanism of solid-state reactions at increasing temperatures. Thermochim Acta. 1971;3:1–12.

    Article  Google Scholar 

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Acknowledgements

This work was supported by the PN-II-RU-TE-2014-4-0515 to Gabriela Vlase.

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Authors and Affiliations

  1. Research Center: Thermal Analysis in Environmental Problems, West University of Timisoara, 16 Pestalozzi Street, 300115, Timişoara, Romania

    Mădălina Mateescu, Mihaela Budiul, Paul Albu & Titus Vlase

  2. Department of Pharmaceutical Sciences, Faculty of Pharmacy, “Vasile Goldis” West University of Arad, 86 L. Rebreanu St., 310414, Arad, Romania

    Paul Albu

  3. Faculty of Pharmacy, University of Medicine and Pharmacy “Victor Babeş”, 2 EftimieMurgu Square, 300041, Timişoara, Romania

    Gabriela Vlase

Authors
  1. Mădălina Mateescu
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  2. Mihaela Budiul
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  3. Paul Albu
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  4. Gabriela Vlase
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  5. Titus Vlase
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Correspondence to Titus Vlase.

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Mateescu, M., Budiul, M., Albu, P. et al. Thermal behavior and kinetic study of degradation for adamantan-2-one versus memantine hydrochloride. J Therm Anal Calorim 130, 391–396 (2017). https://doi.org/10.1007/s10973-017-6443-9

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  • DOI: https://doi.org/10.1007/s10973-017-6443-9

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