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Use of phyllosilicate clay mineral to increase solubility olanzapine

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Abstract

Phyllosilicates have interesting properties, such as high capacity of ion exchange, adsorption, physicochemical stability and low/null toxicity, and thus, they are a promising material in pharmaceutical studies. Olanzapine (OLZ), used in the treatment of schizophrenia, is a drug of high cost and low water solubility, which are an obstacle to its use. In this work, an oral delivery system was developed using phyllosilicate (PHY-NT) and OLZ together to increase its solubility. PHY-NT was synthesized by sol–gel method, and then, OLZ was adsorbed creating the system called PHY-NT:OLZ. Thermal analysis was performed to investigate possible interactions between olanzapine and phyllosilicate. a sharp endothermic peak at 468 K was observed, which corresponds to the melting process of OLZ. When OLZ was added to PHY-NT, this peak was absent, suggesting an efficient denaturation of its crystal lattice. FTIR spectroscopy and X-ray powder diffraction were performed as complementary techniques to adequately support thermal analysis results. The created system caused a considerable increase in OLZ dissolution efficiency, and more than 80 % of the drug was released from PHY-NT:OLZ after 20 min. Drug release was evaluated in vitro and showed a Fickian diffusion-based pattern. Thus, results suggest that PHY-NT can be used as an alternative to increase drug dissolution rate of OLZ, expanding applications of these materials.

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Acknowledgements

The authors thank Capes, Facepe and CNPq for financial support.

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Authors and Affiliations

  1. Core of Medicines and Corelated Quality Control, Department of Pharmaceutical Sciences, Universidade Federal de Pernambuco, Arthur de Sá, s/n, Recife, PE, 50740-521, Brazil

    M. L. C. M. Gonçalves, M. A. M. Lyra, D. Nadvorny, A. C. S. G. Vilarinho, M. F. L. R. Soares & J. L. Soares-Sobrinho

  2. Chemistry Department, Centro de Ciências Exatas e da Natureza, Universidade Federal da Paraíba, João Pessoa, PB, 58059-900, Brazil

    F. J. V. E. Oliveira

  3. Analytical Center, Universidade Federal do Vale de São Francisco, Av. José de Sá Maniçoba, s/n, Petrolina, PE, 56304-917, Brazil

    L. A. Rolim

  4. Interdisciplinary Laboratory for Advanced Materials, Centro de ciências exatas e da Natureza, Universidade Federal do Piauí, Teresina, PI, 64049-550, Brazil

    L. C. C. Nunes & E. C. Silva-Filho

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  1. M. L. C. M. Gonçalves
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  2. M. A. M. Lyra
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  5. D. Nadvorny
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  7. L. C. C. Nunes
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  8. M. F. L. R. Soares
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  9. E. C. Silva-Filho
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  10. J. L. Soares-Sobrinho
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Correspondence to J. L. Soares-Sobrinho.

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Gonçalves, M.L.C.M., Lyra, M.A.M., Oliveira, F.J.V.E. et al. Use of phyllosilicate clay mineral to increase solubility olanzapine. J Therm Anal Calorim 127, 1743–1750 (2017). https://doi.org/10.1007/s10973-016-5719-9

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  • DOI: https://doi.org/10.1007/s10973-016-5719-9

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