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In vitro biodegradation and biocompatibility of gelatin/montmorillonite-chitosan intercalated nanocomposite

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Abstract

The intercalated nanocomposite of gelatin/montmorillonite-chitosan (Gel/MMT-CS) was prepared via the solution intercalation process. In vitro degradation tests showed that the nanocomposite had a lower degradation rate than Gel-CS composite. And the introduced intercalation structure endowed Gel/MMT-CS nanocomposite with a controllable degradation rate when changing the MMT content. Cells attachment, spread and proliferation on the Gel/MMT-CS membranes were investigated by scanning electron microscopy (SEM) and mitochondrial activity assay. The results provided evidences of good adhesion, proliferation and morphology of rat stromal stem cells on Gel/MMT-CS membranes compared to the tissue culture plates (TCPs), making the Gel/MMT-CS nanocomposite a promising candidate towards tissue engineering.

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Acknowledgment

The authors wish to thank the National Natural Science Foundation of China, through Grant No. 20204008, for supporting this research.

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  1. College of Materials Science and Engineering, Tianjin University, Tianjin, 300072, P.R. China

    Hong Zhuang, Jun Ping Zheng, Hong Gao & Kang De Yao

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  1. Hong Zhuang
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  2. Jun Ping Zheng
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  3. Hong Gao
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Correspondence to Jun Ping Zheng.

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Zhuang, H., Zheng, J.P., Gao, H. et al. In vitro biodegradation and biocompatibility of gelatin/montmorillonite-chitosan intercalated nanocomposite. J Mater Sci: Mater Med 18, 951–957 (2007). https://doi.org/10.1007/s10856-006-0093-y

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