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Thermal behavior and decomposition of oxytetracycline hydrochloride

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Abstract

The thermal behavior of oxytetracycline hydrochloride (OTC) antibiotic was evaluated using TG–DTA, TG–FTIR and DSC. Information was obtained regarding thermal stability and decomposition steps. From TG–FTIR, it was possible to identify some of the products of its thermal decomposition as chloridric acid, water, isocyanic acid, dimethylamine, methane, carbonic gas and ammonia, and carbon dioxide from the decomposition of the isocyanic acid. According to DSC data, melting occurred concomitantly with decomposition. The TG/DTG, DTA and DSC curves, together with the FTIR spectra of the volatile decomposition products, were used to propose a mechanism for oxytetracycline decomposition.

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Acknowledgements

The authors are grateful to agencies FAPESP (Process: 2012/09911-3), CNPq, as well as Procontes/USP and CiTecBio/NAP’s–PRP/USP programs, for support.

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Authors and Affiliations

  1. Departamento de Química e Física Molecular, Instituto de Química de São Carlos, USP, Av. Trabalhador São-Carlense, 400, Caixa Postal 780, São Carlos, São Paulo, CEP 13560-970, Brazil

    Priscila Cervini, Beatriz Ambrozini, Luis Carlos M. Machado, Ana Paula Garcia Ferreira & Éder Tadeu Gomes Cavalheiro

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  1. Priscila Cervini
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  2. Beatriz Ambrozini
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  3. Luis Carlos M. Machado
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  4. Ana Paula Garcia Ferreira
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  5. Éder Tadeu Gomes Cavalheiro
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Correspondence to Éder Tadeu Gomes Cavalheiro.

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Cervini, P., Ambrozini, B., Machado, L.C.M. et al. Thermal behavior and decomposition of oxytetracycline hydrochloride. J Therm Anal Calorim 121, 347–352 (2015). https://doi.org/10.1007/s10973-015-4447-x

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  • DOI: https://doi.org/10.1007/s10973-015-4447-x

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