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Characterization and evaluation of free and nanostructured ursolic acid incorporated in cosmetic formulation using thermal analysis

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Abstract

The ursolic acid (UA) increases the skin’s barrier function and acts in epidermal differentiation of keratinocytes in the epidermis, promoting cell renewal. Besides the mentioned properties UA also has antioxidant, antimicrobial, and anti-irritant functions to cosmetic formulations. Thus, it is necessary formulation studies to insure the development of quality cosmetic products containing this active, increasing its antioxidant potential within nanoparticles. This study aims to characterize and evaluate the thermal behavior of UA in free and nanostructured forms, and both incorporated into a cosmetic base formulation, using thermogravimetry and differential scanning calorimetry. Through the study were observed that free UA, in the embedded nanoparticles and in base formulation exhibited different behavior in similar thermal profile and relative to the presence of UA. The UA remained stable to a temperature of 250 °C and the technique has been shown to be effective for characterizing UA, evaluate water content, and stability of the formulation base.

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Acknowledgements

The author would like to thank Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), for financial support, HighChem for the donation of ursolic acid, Mapric, Basf, and Vital Especialidades for the donation of raw materials.

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Authors and Affiliations

  1. Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, USP-SP, São Paulo, SP, 05508-900, Brazil

    Mariana Mandelli de Almeida, Nádia Araci Bou-Chacra, André Rolim Baby, Telma Mary Kaneko & Maria Valéria Robles Velasco

  2. Department of Fundamental Chemistry, Chemistry Institute, University of São Paulo, USP-SP, São Paulo, SP, 05508-900, Brazil

    Cibele Rosana Ribeiro de Castro Lima & Jivaldo do Rosário Matos

  3. Department of Exact and Earth Sciences, Faculty of Chemistry, University Federal of São Paulo, Campus Diadema, Diadema, SP, 09972-270, Brazil

    Elder Moscardini Filho & Lucildes Pita Mercuri

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  1. Mariana Mandelli de Almeida
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  2. Nádia Araci Bou-Chacra
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  3. Cibele Rosana Ribeiro de Castro Lima
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  6. Lucildes Pita Mercuri
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  9. Maria Valéria Robles Velasco
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Correspondence to Mariana Mandelli de Almeida.

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de Almeida, M.M., Bou-Chacra, N.A., de Castro Lima, C.R.R. et al. Characterization and evaluation of free and nanostructured ursolic acid incorporated in cosmetic formulation using thermal analysis. J Therm Anal Calorim 115, 2401–2406 (2014). https://doi.org/10.1007/s10973-013-3346-2

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  • DOI: https://doi.org/10.1007/s10973-013-3346-2

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