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Molecular modeling, spectral, and biological studies of 4-formylpyridine-4 N-(2-pyridyl) thiosemicarbazone (HFPTS) and its Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Cd(II), Hg(II), and UO2(II) complexes

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Abstract

The present work describes the preparation and characterization of some metal ion complexes derived from 4-formylpyridine-4 N-(2-pyridyl)thiosemicarbazone (HFPTS). The complexes have the formula; [Cd(HFPTS)2H2O]Cl2, [CoCl2(HPTS)]·H2O, [Cu2Cl4(HPTS)]·H2O, [Fe (HPTS)2Cl2]Cl·3H2O, [Hg(HPTS)Cl2]·4H2O, [Mn(HPTS)Cl2]·5H2O, [Ni(HPTS)Cl2]·2H2O, [UO2(FPTS)2(H2O)]·3H2O. The complexes were characterized by elemental analysis, spectral (IR, 1H-NMR and UV–Vis), thermal and magnetic moment measurements. The neutral bidentate coordination mode is major for the most investigated complexes. A mononegative bidentate for UO2(II), and neutral tridentate for Cu(II). The tetrahedral arrangement is proposed for most investigated complexes. The biological investigation displays the toxic activity of Hg(II) and UO2(II) complexes, whereas the ligand displays the lowest inhibition activity toward the most investigated microorganisms.

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Acknowledgments

The financial support by the Deanship of Scientific Research (Project No. 130164) King Faisal University, Saudi Arabia is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt

    Nashwa M. El Metwally & Usama El-Ayaan

  2. Department of Chemistry, Faculty of Science of Girls, King Khaled University, Hofuf, Saudi Arabia

    Nashwa M. El Metwally

  3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt

    Reem Arafa

  4. Department of Chemistry, College of Science, King Faisal University, P.O. Box 380, Hofuf, 31982, Saudi Arabia

    Usama El-Ayaan

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  1. Nashwa M. El Metwally
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  2. Reem Arafa
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Correspondence to Nashwa M. El Metwally.

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El Metwally, N.M., Arafa, R. & El-Ayaan, U. Molecular modeling, spectral, and biological studies of 4-formylpyridine-4 N-(2-pyridyl) thiosemicarbazone (HFPTS) and its Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Cd(II), Hg(II), and UO2(II) complexes. J Therm Anal Calorim 115, 2357–2367 (2014). https://doi.org/10.1007/s10973-013-3065-8

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