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Structure and Biological Activity of Trichlorophenyl-Thiosemicarbazone and its Complexes with Some Transition Metal Cations

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Abstract

The complexes of 4-(2,4,6-trichlorophenyl)-3-thiosemicarbazide (HL1) with transition metal cations VO(II), Co(II), Ni(II), Cu(II), Pd(II), and Pt(II) are prepared and characterized using elemental and thermal analyses, UV-visible spectrophotometry, FTIR, mass, and NMR spectroscopy, X-ray diffraction, and molar conductance and magnetic susceptibility measurements. The results show that the prepared chelates have the following chemical formulae and structures: [(VO)2(L1)(SO4)(C2H5O)·H2O] (square based pyramidal structure), [Co2(HL1)Cl3C2H5OH]·Cl (square planar structure), [Ni(HL1)Cl2]·3H2O (square planar structure), [Cu(L1)2(H2O)2] (octahedral structure), [Pd(HL1)Cl2]·H2O (weakly distorted square planar structure), and [Pt(HL1)Cl2]·1/2H2O (square planar structure). Generally, the complexes exhibit a high thermal stability, however, the Pd(II) and Pt(II) complexes are more stable than the other complexes. The ligand (HL1), and its complexes are screened for their biological activity. Some of the complexes are found more biologically active than the parent ligand.

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Acknowledgments

The support of the University of Kuwait through the College of Graduate Studies (M.Sc. thesis of Ms. Manal Marzouk) is gratefully acknowledged.

Funding

This work was supported by the Research Sector Projects Unit (RSPU) (Grant numbers: GS01/01, GS01/05, GS02/01, GS03/01, and GS03/08).

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Kuwait University, Safat, State of Kuwait

    A. Shoukry, O. Al-Fulaij, M. Marzouk & N. Aman

Authors
  1. A. Shoukry
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  2. O. Al-Fulaij
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  3. M. Marzouk
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  4. N. Aman
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Correspondence to A. Shoukry.

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The authors declare that they have no conflict of interests.

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Text © The Author(s), 2019, published in Zhurnal Strukturnoi Khimii, 2019, Vol. 60, No. 11, pp. 1892–1900.

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Shoukry, A., Al-Fulaij, O., Marzouk, M. et al. Structure and Biological Activity of Trichlorophenyl-Thiosemicarbazone and its Complexes with Some Transition Metal Cations. J Struct Chem 60, 1818–1826 (2019). https://doi.org/10.1134/S0022476619110167

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  • DOI: https://doi.org/10.1134/S0022476619110167

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