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Spectroscopic, thermal, and dielectric studies of n-butyl 4-(3,4-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4 tetrahydropyrimidine-5-carboxylate crystals

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Abstract

Pyrimidines and its derivatives find different pharmaceutical applications. The n-butyl 4-(3,4 dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4 tetrahydropyrimidine-5-carboxylate (abbreviated as n-butyl THPM) was synthesized. The n-butyl THPM crystals were grown by slow solvent evaporation technique using chloroform as a solvent. Yellowish, coagulated, and semi-transparent crystals having dimensions of 2 × 1.5 mm were grown. The crystals were characterized by powder XRD, FT–IR, SEM, TG–DTA–DSC, 1H-NMR, and dielectric study. The crystals remained stable up to 150 °C and then started decomposing. The DSC suggested both endothermic and exothermic reactions. One broad exothermic peak was observed at 540.3 °C due to complete decomposition of the sample into the gaseous phase and reaction within the products. 1H-NMR spectrum has been carried out to explain the molecular structure. The dielectric study was carried out in the frequency range from 50 Hz to 5 MHz at room temperature. The dielectric constant decreased as the frequency of the applied field increased. The variations of dielectric loss, a.c. conductivity, and a.c. resistivity were also studied with the frequency of the applied field.

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Acknowledgements

The authors are thankful to UGC, New Delhi, for the SAP. The authors are thankful to State Government of Gujarat for providing financial assistance to develop characterization facilities and Prof. P. H. Parsania (HOD of Chemistry Dept.) for his keen interest.

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Authors and Affiliations

  1. Department of Physics, Saurashtra University, Rajkot, 360 005, India

    P. M. Vyas & M. J. Joshi

  2. Department of Chemistry, Saurashtra University, Rajkot, 360 005, India

    A. M. Pansuriya & Y. T. Naliapara

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  1. P. M. Vyas
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  2. A. M. Pansuriya
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  3. Y. T. Naliapara
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  4. M. J. Joshi
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Correspondence to P. M. Vyas.

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Vyas, P.M., Pansuriya, A.M., Naliapara, Y.T. et al. Spectroscopic, thermal, and dielectric studies of n-butyl 4-(3,4-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4 tetrahydropyrimidine-5-carboxylate crystals. J Therm Anal Calorim 114, 839–844 (2013). https://doi.org/10.1007/s10973-013-3016-4

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  • DOI: https://doi.org/10.1007/s10973-013-3016-4

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