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Thermal behavior of some antihistamines

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Abstract

Thermogravimetry (TG), differential scanning calorimetry (DSC), polarized light thermal microscopy (PLTM), as well as X-ray powder diffraction (XRD) and Fourier transformed infrared spectroscopy (FTIR) were used to study the thermal behavior and the chemical structure of cimetidine, famotidine, ranitidine-HCl, and nizatidine. The TG–DSC curves show that the famotidine and ranitidine-HCl suffer decomposition during melting and they are thermally less stable in comparison with cimetidine and nizatidine, the latter being the most stable of all the drugs studied in this study. The DSC curves of famotidine and ranitidine-HCl show exothermic peaks immediately after the melting, confirming the occurrence of thermal decomposition. The DSC curves also show that the cimetidine and nizatidine have some thermal stability after melting. The thermal events shown in the PLTM images are consistent with the results shown in the TG–DSC and DSC curves. The XRD patterns show that the cimetidine and famotidine are less crystalline compared with ranitidine-HCl and nizatidine. The theoretical FTIR bands are in agreement with those obtained experimentally, and in some cases, no difference is observed between the theoretical and experimental values, even being identical in one of the cases.

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Acknowledgements

The authors thank FUNDUNESP, PROPe-UNESP, PROPG-UNESP, FC-UNESP, and POSMAT-UNESP for the financial support. The authors also thank Prof. Dr. Massao Ionashiro by the use their equipment, TG–DTA, DSC, FTIR and the Center for Scientific Computing (NCC/GridUNESP) of Universidade Estadual Paulista (UNESP), Instituto de Quimica de Araraquara, UNESP Campus de Araraquara and CENAPAD—UNICAMP.

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Authors and Affiliations

  1. Departamento de Química, Falculdade de Ciências, UNESP, Bauru, SP, CEP 17033-260, Brazil

    G. L. Perpétuo, D. A. Gálico, R. A. Fugita, A. C. M. Silva & G. Bannach

  2. CEF, Faculdade de Farmácia, Universidade de Coimbra, CEP 3000-548, Coimbra, Portugal

    R. A. E. Castro

  3. CQC, Departamento de Química, Universidade de Coimbra, CEP 3004-535, Coimbra, Portugal

    M. E. S. Eusébio

  4. Instituto de Química—UNESP, Araraquara, SP, CEP 14800-900, Brazil

    O. Treu-Filho

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  1. G. L. Perpétuo
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  2. D. A. Gálico
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  3. R. A. Fugita
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  4. R. A. E. Castro
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  5. M. E. S. Eusébio
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  6. O. Treu-Filho
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  7. A. C. M. Silva
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  8. G. Bannach
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Correspondence to G. Bannach.

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Perpétuo, G.L., Gálico, D.A., Fugita, R.A. et al. Thermal behavior of some antihistamines. J Therm Anal Calorim 111, 2019–2028 (2013). https://doi.org/10.1007/s10973-012-2247-0

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  • DOI: https://doi.org/10.1007/s10973-012-2247-0

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