Skip to main content
SpringerLink
Log in

Thermal, spectral, and thermodynamic studies for evaluation of calf thymus DNA interaction activity of some copper(II) complexes

  • Published:
Journal of Thermal Analysis and Calorimetry Aims and scope Submit manuscript

Abstract

The square-pyramidal copper(II) complexes with ciprofloxacin in the presence of bipyridine derivatives have been synthesized and characterized using elemental analysis, magnetic moment measurement, thermal analysis (TG), IR, mass and reflectance spectra. The thermal denaturation study has been used for evaluating calf thymus DNA interaction activity. Spectral and hydrodynamic measurements have been used for validating the DNA interaction study. The thermodynamic profile was established for proper understanding of DNA binding Gibbs free energy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. Bhattacharya PK, Barton JK. Influence of intervening mismatches on long-range guanine oxidation in DNA duplexes. J Am Chem Soc. 2001;123:8649–56.

    Article  CAS  Google Scholar 

  2. Delaney S, Yoo J, Stemp EDA, Barton JK. Charge equilibration between two distinct sites in double helical DNA. Proc Natl Acad Sci. 2004;101:10511–6.

    Article  CAS  Google Scholar 

  3. Rajski SR, Williams RM. DNA cross-linking agents as antitumor drugs. Chem Rev. 1998;98:2723–96.

    Article  CAS  Google Scholar 

  4. Zhang QL, Liu JG, Xu H, Li H, Liu JZ, Zhou H, Qu LH, Ji LN. Synthesis, characterization and DNA-binding studies of cobalt(III) polypyridyl complexes. Polyhedron. 2001;20:3049–55.

    Article  CAS  Google Scholar 

  5. Das S, Kumar GS. Molecular aspects on the interaction of phenosafranine to deoxyribonucleic acid: model for intercalative drug–DNA binding. J Mol Struc. 2008;872:56–63.

    Article  CAS  Google Scholar 

  6. Nafisi S, Manouchehri F, Riahi HAT, Varavipour M. Structural features of DNA interaction with caffeine and theophylline. J Mol Struc. 2008;875:392–9.

    Article  CAS  Google Scholar 

  7. Kornilova SV, Miskovsky P, Tomkova A, Kapinos LE, Hackl EV, Andrushchenko VV, Grigoriev DN, Blagoi YP. Vibrational spectroscopic studies of the divalent metal ion effect on DNA structural transitions. J Mol Struc. 1997;408:219–23.

    Article  Google Scholar 

  8. Ng CH, Ong HKA, Kong CW, Tan KW, Rahman RN, Yamin BM, Ng SW. Factors affecting the nucleolytic cleavage of DNA by (N, N′-ethylenendiaminediacetato)metal(II) complexes, M(edda). Crystal structure of Co(edda). Polyhedron. 2006;25:3118–26.

    Article  CAS  Google Scholar 

  9. Zuzzi S, Onori G, Cametti C. Thermal stability of DNA in DNA–induced dotap liposome aggregates. J Therm Anal Calorim. 2008;93(2):527–33.

    Article  CAS  Google Scholar 

  10. Khvedelidze M, Mdzinarashvili T, Partskhaladze T, Nafee N, Schaefer UF, Lehr CM, Schneider M. Calorimetric and spectrophotometric investigation of PLGA nanoparticles and their complex with DNA. J Therm Anal Calorim. 2010;99:337–48.

    Article  CAS  Google Scholar 

  11. Vogel AI. Textbook of quantitative inorganic analysis. 4th ed. London: ELBS and Longman; 1978.

  12. Neve F, Crispini A, Campagna S, Serroni S. Synthesis, structure, photophysical properties, and redox behavior of cyclometalated complexes of iridium(III) with functionalized 2,2′-bipyridines. Inorg Chem. 1999;38:2250–8.

    Article  CAS  Google Scholar 

  13. Marmur J. A procedure for the isolation of deoxyribonucleic acid from micro-organisms. J Mol Biol. 1961;3:208–18.

    Article  CAS  Google Scholar 

  14. Reichmann ME, Rice SA, Thomas CA, Doty P. A further examination of the molecular weight and size of desoxypentose nucleic acid. J Am Chem Soc. 1954;76:3047–53.

    Article  CAS  Google Scholar 

  15. Chaires JB, Dattagupta N, Crothers DM. Studies on interaction of anthracycline antibiotics and deoxyribonucleic acid: equilibrium binding studies on the interaction of daunomycin with deoxyribonucleic acid. Biochemistry. 1982;21:3933–40.

    Article  CAS  Google Scholar 

  16. Cohen G, Eisenberg H. Viscosity and sedimentation study of sonicated DNA–proflavine complexes. Biopolymers. 1969;8:45–55.

    Article  CAS  Google Scholar 

  17. Figgis BN, Lewis J, Wilkins RG. Modern coordination chemistry: principles and methods. New York: Willey Interscience; 1960.

    Google Scholar 

  18. Leban I, Turel I, Bukovec N. Synthesis, characterization, and crystal structure of a copper(II) complex with quinolone family member (ciprofloxacin): bis(1)-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazin-1ylquinoline-3-carboxylate) copper(II) chloride hexahydrate. J Inorg Biochem. 1994;56:273–82.

    Article  Google Scholar 

  19. Nakamoto K. Infrared and Raman spectra of inorganic and coordination compounds. New York: Wiley Interscience; 1986.

    Google Scholar 

  20. Anacona JR, Rodriguez I. Synthesis and antibacterial activity of cephalexin metal complexes. J Coord Chem. 2004;57:1263–9.

    Article  CAS  Google Scholar 

  21. Deacon GB, Philips RJ. Relationships between the carbon-oxygen stretching frequencies of carboxylato complexes and the type of carboxylate coordination. Coord Chem Rev. 1980;33:227–50.

    Article  CAS  Google Scholar 

  22. Chohan ZH, Suparan CT, Scozzafava A. Metal binding and antibacterial activity of ciprofloxacin complexes. J Enzym Inhib Med Chem. 2005;20:303–7.

    Article  CAS  Google Scholar 

  23. Turel I, Leban I, Bukovec N. Crystal structure and characterization of the bismuth(III) compound with quinolone family member (ciprofloxacin). Antibacterial study. J Inorg Biochem. 1997;66:241–5.

    Article  CAS  Google Scholar 

  24. Patel SH, Pansuriya PB, Chhasatia MR, Parekh HM, Patel MN. Coordination chain polymeric assemblies of trivalent lanthanides with multidentate Schiff base. Synthetic, spectral investigation and thermal aspects. J Therm Anal Calorim. 2008;91(2):413–8.

    Article  CAS  Google Scholar 

  25. Parekh HM, Panchal PK, Patel MN. Transition metal(ii) ions with dinegative tetradentate Schiff base. J Therm Anal Calorim. 2006;86(3):803–7.

    Article  CAS  Google Scholar 

  26. Freedman HH. Intramolecular H-bonds. I. A spectroscopic study of the hydrogen bond between hydroxyl and nitrogen. J Am Chem Soc. 1961;83:2900–5.

    Article  CAS  Google Scholar 

  27. Badea M, Olar R, Marinescu D, Uivarosi V, Nicolescu TO, Iacob D. Thermal study of some new quinolone ruthenium(III) complexes with potential cytostatic activity. J Therm Anal Calorim. 2010;99:829–34.

    Article  CAS  Google Scholar 

  28. Ababei LV, Kriza A, Musuc AM, Andronescu C, Rogozea EA. Thermal behaviour and spectroscopic studies of complexes of some divalent transitional metals with 2-benzoil-pyridilizonicotinoylhydrazone. J Therm Anal Calorim. 2010;101:987–96.

    Article  CAS  Google Scholar 

  29. Kose DA, Gokce G, Gokce S, Uzun I. Bis(N,N-diethylnicotinamide) p-chlorobenzoate complexes of Ni(II), Zn(II) and Cd(II):Synthesis and characterization. J Therm Anal Calorim. 2009;95:247–51.

    Article  CAS  Google Scholar 

  30. Dziewulska-Kułaczkowska A. Manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II) complexes with 4-oxo-4H–1-benzopyran-3-carboxaldehyde. Thermal, spectroscopic and magnetic characterization. J Therm Anal Calorim. 2010;101:1019–26.

    Article  Google Scholar 

  31. Zupancic M, Cerc Korosec R, Bukovec P. The thermal stability of ciprofloxacin complexes with magnesium(II), zinc(II) and cobalt(II). J Therm Anal Calorim. 2001;63:787–95.

    Article  CAS  Google Scholar 

  32. El–Metwaly NM. Spectral and biological investigation of 5-hydroxyl-3-oxopyrazoline 1-carbothiohydrazide and its transition metal complexes. Trans Met Chem. 2007;32:88–94.

    Article  Google Scholar 

  33. Waring MJ. Complex formation between ethidium bromide and nucleic acids. J Mol Biol. 1965;13:269.

    Article  CAS  Google Scholar 

  34. Kelly JM, Tossi AB, McConell DJ, OhUigin C. A study of the interactions of some polypyridylruthenium(II) complexes with DNA using fluorescence spectroscopy, topoisomerisation and thermal denaturation. Nucleic Acids Res. 1985;13:6017–34.

    Article  CAS  Google Scholar 

  35. Neyhart GA, Grover N, Smith SR, Kalsbeck WA, Fairly TA, Cory M, Thorp HH. Binding and kinetics studies of oxidation of DNA by oxoruthenium(IV). J Am Chem Soc. 1993;115:4423–8.

    Article  CAS  Google Scholar 

  36. Wheate NJ, Brodie CR, Collins JG, Kemp S, Aldrich-Wright JR. DNA intercalators in cancer therapy: organic and inorganic drugs and their spectroscopic tools of analysis. Mini Rev Med Chem. 2007;7:627–48.

    Article  CAS  Google Scholar 

  37. Hertzberg RP, Dervan PB. Cleavage of double helical DNA by methidium-propyl-EDTA-iron(II). J Am Chem Soc. 1982;104:313–5.

    Article  CAS  Google Scholar 

  38. Haq I, Lincoln P, Suh D, Norden D, Chowdhry BZ, Chaires JB. Interaction of DELTA- and LAMBDA-[Ru(phen)2DPPZ]2+ with DNA: a calorimetric and equilibrium binding study. J Am Chem Soc. 1995;117:4788–96.

    Article  CAS  Google Scholar 

  39. Mudasir, Wijaya K, Yoshioka N, Inoue H. DNA binding of iron(II) complexes with 1,10-phenanthroline and 4,7-diphenyl-1, 10-phenanthroline: salt effect, ligand substituent effect, base pair specificity and binding strength. J Inorg Biochem. 2003;94:263–71.

    Article  CAS  Google Scholar 

  40. Satyanarayana S, Dabrowiak JC, Chaires JB. Neither DELTA- nor LAMBDA-tris(phenanthroline)ruthenium(II) binds to DNA by classical intercalation. Biochemistry. 1992;31:9319–24.

    Article  CAS  Google Scholar 

  41. Chaires B, Satyanarayana S, Suh D, Fokt I, Przewloka T, Priebe W. Parsing the free energy of anthracycline antibiotic binding to DNA. Biochemistry. 1996;35:2047–53.

    Article  CAS  Google Scholar 

  42. Sigman DS, Graham DR, Marshall LE, Reich KA. Cleavage of DNA by coordination complexes. Superoxide formation in the oxidation of 1,10-phenanthroline-cuprous complexes by oxygen—relevance to DNA—cleavage reaction. J Am Chem Soc. 1980;102:5419–21.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388 120, Gujarat, India

    Mohan N. Patel, Bhupesh S. Bhatt & Promise A. Dosi

Authors
  1. Mohan N. Patel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bhupesh S. Bhatt
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Promise A. Dosi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mohan N. Patel.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Patel, M.N., Bhatt, B.S. & Dosi, P.A. Thermal, spectral, and thermodynamic studies for evaluation of calf thymus DNA interaction activity of some copper(II) complexes. J Therm Anal Calorim 107, 55–64 (2012). https://doi.org/10.1007/s10973-011-1554-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10973-011-1554-1

Keywords

Search

Navigation