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Thermoanalytical method for predicting the hydration effect permanency of dermal semisolid preparations

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Abstract

Our aim was to develop potential dermal drug delivery systems (DDSs) with a good and lasting moisturizing effect. Lyotropic liquid crystals (LLCs), gel-emulsions and hydrogels were investigated by means of thermogravimetry, which can give information about the structure of these preparations, and we could study the water binding mechanisms indirectly in them. We found that the preparations with a complex structure and strong water bonds hydrate the skin well and lastingly by in vivo tests. Since the thermoanalytical results correlate with the in vivo test results, this method could be suited for predicting the moisturizing effect of the vehicles and provide the possibility to select the potential semisolid DDSs for in vivo tests cost and time effectively.

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, University of Szeged, Eötvös u. 6, H-6720, Szeged, Hungary

    Eszter Csizmazia, Mária Budai-Szűcs, István Erős, Zsolt Makai, Piroska Szabó-Révész & Erzsébet Csányi

  2. Dr Derm Equipment Ltd., Fény u. 2, H-1024, Budapest, Hungary

    Gábor Varju

Authors
  1. Eszter Csizmazia
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  2. Mária Budai-Szűcs
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  3. István Erős
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  4. Zsolt Makai
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  5. Piroska Szabó-Révész
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  6. Gábor Varju
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  7. Erzsébet Csányi
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Correspondence to Erzsébet Csányi.

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Csizmazia, E., Budai-Szűcs, M., Erős, I. et al. Thermoanalytical method for predicting the hydration effect permanency of dermal semisolid preparations. J Therm Anal Calorim 102, 313–316 (2010). https://doi.org/10.1007/s10973-010-0693-0

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  • DOI: https://doi.org/10.1007/s10973-010-0693-0

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