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Thermal analysis and crystallization from melts

β-adrenergic compounds

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Abstract

The growth of atenolol, pindolol and betaxolol hydrochloride from melt was investigated by differential scanning calorimetry (DSC) and polarized light thermal microscopy (PLTM). Phase transitions occurring on cooling and subsequent reheating runs performed between −160 °C and a temperature above the respective melting points were studied by DSC. The thermal cycles were also followed by PLTM. Details about the dynamic of the crystallization front taken from microscopic observations are given. An explanation of the results on the basis of molecular supramolecular recognition is advanced.

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Authors and Affiliations

  1. Department of Chemistry, University of Coimbra, Rua Larga, 3004-535, Coimbra, Portugal

    M. T. S. Rosado, S. C. C. Nunes, M. S. C. Cruz & J. S. Redinha

  2. Faculty of Pharmacy, University of Coimbra, Rua do Norte, 3000-295, Coimbra, Portugal

    J. Canotilho & R. A. E. Castro

Authors
  1. J. Canotilho
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  2. R. A. E. Castro
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  3. M. T. S. Rosado
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  4. S. C. C. Nunes
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  5. M. S. C. Cruz
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  6. J. S. Redinha
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Corresponding author

Correspondence to J. S. Redinha.

Additional information

The coauthors would like to dedicate this manuscript to the memory of Professor M. Luísa P. Leitão for her invaluable contribution to the advance of thermal analysis in their research center.

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Canotilho, J., Castro, R.A.E., Rosado, M.T.S. et al. Thermal analysis and crystallization from melts. J Therm Anal Calorim 100, 423–429 (2010). https://doi.org/10.1007/s10973-009-0645-8

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  • DOI: https://doi.org/10.1007/s10973-009-0645-8

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