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Polymorphism and solvation of indomethacin

Characterization of an indomethacin–tetrahydrofuran solvate leading to phase I

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Abstract

Indomethacin crystallizes from solutions in tetrahydrofuran as a solvate exhibiting the mole ratio 1 indomethacin:2 tetrahydrofuran. Upon heating, desolvation into indomethacin phase I occurs through partial amorphization and transitory formation of a phase, which is different from the crystallographically known polymorphs. The X-ray powder diffraction pattern of the solvate was tentatively indexed on a triclinic lattice (a = 31.454(5) Å, b = 17.883(3) Å, c = 10.551(2) Å, α = 70.55(2)°, β = 105.31(2)°, γ = 136.70(1)°). Assuming Z = 6 (1 indomethacin + 2 tetrahydrofuran) formula units per unit cell, the solvate’s specific volume is similar to the value calculated using additivity.

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Authors and Affiliations

  1. Laboratoire de Chimie Physique, EA4066, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, 4 avenue de l’Observatoire, 75006, Paris, France

    Béatrice Nicolaï, René Céolin & Ivo B. Rietveld

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  1. Béatrice Nicolaï
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  2. René Céolin
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  3. Ivo B. Rietveld
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Correspondence to Ivo B. Rietveld.

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Nicolaï, B., Céolin, R. & Rietveld, I.B. Polymorphism and solvation of indomethacin. J Therm Anal Calorim 102, 211–216 (2010). https://doi.org/10.1007/s10973-009-0412-x

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  • DOI: https://doi.org/10.1007/s10973-009-0412-x

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