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Thermal analysis of lipoic acid and evaluation of the compatibility with excipientes

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Abstract

Differential scanning calorimetry (DSC) was used as a screening technique for assessing the compatibility of lipoic acid with some currently employed cosmetic excipients. In the first phase of the study DSC was used as a tool to detect any interaction. Based on the DSC results alone, methyl p-hydroxybenzoate, propyl p-hydroxybenzoate, butylated hydroxytoluene, non ionic self emulsifying wax, propylene glycol and acetylated lanolin were found to exhibit interaction with lipoic acid. Stressed binary mixtures (stored at 50 °C for 1 week) of lipoic acid and excipients were evaluated by HPLC. Binary mixtures were evaluated by IR spectroscopy.

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Acknowledgements

This work was supported by grant B116/2004-2008 to M. T. Pizzorno and A. I. Segall from UBA.

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Authors and Affiliations

  1. Cátedra de Control de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 1113, Buenos Aires, Argentina

    María A. Moyano & Adriana I. Segall

  2. Cátedra de Farmacognosia, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 1113, Buenos Aires, Argentina

    Adriana M. Broussalis

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  1. María A. Moyano
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  2. Adriana M. Broussalis
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  3. Adriana I. Segall
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Correspondence to Adriana I. Segall.

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Moyano, M.A., Broussalis, A.M. & Segall, A.I. Thermal analysis of lipoic acid and evaluation of the compatibility with excipientes. J Therm Anal Calorim 99, 631–637 (2010). https://doi.org/10.1007/s10973-009-0351-6

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  • DOI: https://doi.org/10.1007/s10973-009-0351-6

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