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Application of thermal analysis in study of binary mixtures with metformin

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Abstract

Thermal analysis is an essential analytical tool in development of new formulations as well as to study the interaction between drugs and excipients. This work aims to investigate the possible interactions between metformin and excipients as microcrystalline cellulose (Microcel MC101®), starch sodium glycolate (Explosol®), sodium croscarmellose (Explosel®), PVP K30, magnesium stearate, starch and lactose, usually employed in pharmaceutical products. TG, DSC and DTA techniques were used for the thermal characterization to track if the thermal properties of the drug substance were modified in the mixture. Disregard of the starch and lactose systems, no changes in thermal behavior of mixtures were found. Thermogravimetric studies (TG) of metformin and its binary mixtures showed different thermal behavior.

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References

  1. H. Amini, A. Ahmadiani and P. Gazerani, J. Chrom. B., 824 (2005) 319.

    Article  CAS  Google Scholar 

  2. F. Balestrieri, A. D. Magri, A. L. Magri, D. Marini and A. Sacchini, Thermochim. Acta, 285 (1996), 337.

    Article  CAS  Google Scholar 

  3. R. O. Macêdo, A. G. de Souza and A. M. C. Macêdo, J. Thermal Anal., 49 (1997) 937.

    Article  Google Scholar 

  4. D. Kiss, R. Zelkó, Cs. Novák and Zs. Éhen, J. Therm. Anal. Cal., 84 (2006) 447.

    Article  CAS  Google Scholar 

  5. L. C. S. Cides, A. A. S. Araújo, M. Santos-Filho and J. R. Matos, J. Therm. Anal. Cal., 84 (2006) 441.

    Article  CAS  Google Scholar 

  6. British Pharmacopoeia, version 10.0, 2005.

  7. R. K. Verna and S. Garg, J. Pharm. Biomed. Anal., 38 (2005) 633.

    Article  Google Scholar 

  8. G. G. G. Oliveira, H. G. Ferraz and J. R. Matos, J. Therm. Anal. Cal., 79 (2005) 267.

    Article  CAS  Google Scholar 

  9. F. S. de Souza, A. P. Gomes Barreto and R. O. Macêdo, J. Therm. Anal. Cal., 64 (2001) 739.

    Article  Google Scholar 

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Authors and Affiliations

  1. Pharmaceutical Sciences Department, Federal University of Pernambuco, UFPE, Prof. Moraes Rego Avenue, 1235, University City, Zip. 50670-901, Recife, PE, Brazil

    Ana Flávia Oliveira Santos, A. F. D. Medeiros, Márcia Ferraz Pinto & D. P. de Santana

  2. Unified Laboratory of Medicine Development and Assay, LUDEM, Federal University of Paraiba, UFPB, Campus I, Zip. 58059-900, João Pessoa, PB, Brazil

    I. D. Basílio Jr, F. S. de Souza & R. O. Macêdo

Authors
  1. Ana Flávia Oliveira Santos
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  2. I. D. Basílio Jr
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  3. F. S. de Souza
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  4. A. F. D. Medeiros
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  5. Márcia Ferraz Pinto
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  6. D. P. de Santana
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  7. R. O. Macêdo
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Correspondence to Ana Flávia Oliveira Santos.

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Santos, A.F.O., Basílio, I.D., de Souza, F.S. et al. Application of thermal analysis in study of binary mixtures with metformin. J Therm Anal Calorim 93, 361–364 (2008). https://doi.org/10.1007/s10973-007-7876-3

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  • DOI: https://doi.org/10.1007/s10973-007-7876-3

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